Evaluation of traditional medicinal plant, Cissus setosa Roxb. (Vitaceae) for antiulcer property
| Autor: | Subramaniam Paulsamy, Chinnamaruthu Jayachitra, Mohammad Ajmal Ali, Fahad M.A. Al-Hemaid, Jamuna S |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Vitaceae 030226 pharmacology & pharmacy 03 medical and health sciences chemistry.chemical_compound Ethanol induced ulcer 0302 clinical medicine Pepsin Cissus setosa medicine Potency Pylorus ligation lcsh:QH301-705.5 Ethanol Acute toxicity Agricultural and Biological Sciences(all) Traditional medicine biology business.industry Stomach biology.organism_classification digestive system diseases 030104 developmental biology medicine.anatomical_structure chemistry Biochemistry lcsh:Biology (General) biology.protein Aerial parts General Agricultural and Biological Sciences business |
| Zdroj: | Saudi Journal of Biological Sciences, Vol 25, Iss 2, Pp 293-297 (2018) |
| Popis: | Cissus setosa is an indigenous medicinal herb commonly used for the treatment of gastro ulcers. In the current investigation the aerial methanolic extract of C. setosa was investigated for their antiulcer activity using pylorus ligation and ethanol in experimental rats. The extract was administered at the doses of 200 and 400 mg/kg b.w. orally for 3 days. However, higher dose of the extract subsequently reduced gastric ulcer induced aberrations by pylorus ligation (70.05%) and ethanol (78.16%) as judged by their altered biochemical parameters such as free acidity, total acidity, total carbohydrate, total protein and pepsin activity. Furthermore, macroscopic examination of rat’s stomach also showed that the pretreatment with methanolic extract notably lowered the pylorus ligation and ethanol induced ulcers. As perceived in the present study, evidently, our findings basically supports the potency of the methanol extracts of C. setosa to treat gastrointestinal related disorders, thus lends pharmacological credence to the suggested folklore use. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|