Self-healing hydrogel with cross-linking induced thermo-response regulated light emission property
| Autor: | Baozhong Xi, Yingna He, Haifeng Zhao, Yan Yang, Xuemeng Wang, Fangjie Hou, Jianglei Qin, Wenjuan Li |
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| Rok vydání: | 2019 |
| Předmět: |
Luminescence
macromolecular substances 02 engineering and technology 01 natural sciences Lower critical solution temperature chemistry.chemical_compound Colloid and Surface Chemistry Drug Delivery Systems 0103 physical sciences Stilbenes Copolymer Humans Physical and Theoretical Chemistry chemistry.chemical_classification Acrylamide Antibiotics Antineoplastic 010304 chemical physics technology industry and agriculture Temperature Hydrogels Surfaces and Interfaces General Medicine Tetraphenylethylene Polymer Hydrogen-Ion Concentration 021001 nanoscience & nanotechnology Fluorescence Drug Liberation Cross-Linking Reagents chemistry Chemical engineering Doxorubicin Drug delivery Self-healing hydrogels Light emission 0210 nano-technology Biotechnology |
| Zdroj: | Colloids and surfaces. B, Biointerfaces. 183 |
| ISSN: | 1873-4367 |
| Popis: | With increasing attention paid to smart materials, self-healing hydrogels with thermo-responses have been greatly developed in the past several years. At the same time, fluorescent or light emitting polymers have been studied for use as bioimaging tools and drug delivery vehicles. In this research, thermo-responsive self-healing hydrogels with aggregation-induced emission (AIE) property were prepared from tetraphenylethylene (TPE) containing TPE-poly(N,N-dimethylacrylamide-stat-Diacetone acrylamide) [TPE-P(DMA-stat-DAA)] cross-linked by diacylhydrazide. In addition to self-healing based on reversible acylhydrazone bond, the copolymer and hydrogels showed thermo-responses. The lower critical solution temperature (LCST) of the hydrogels was regulated to body temperature. Based on the AIE property of the TPE unit, the hydrogels showed an enhanced light emitting property above the LCST, which was regulated by temperature change. The in vitro cytotoxicity experiment showed that the hydrogels are not toxic, and the DOX release rate can be enhanced by low pH values, which endowed this kind of thermo-responsive light emitting hydrogel with great potential for applications in bio-diagnosis, drug delivery, artificial organs with light sensitive detection, etc. |
| Databáze: | OpenAIRE |
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