Bladder Versus Enteric Drainage of Exocrine Secretions in Pancreas Transplantation: A Retrospective Analysis of the United Network for Organ Sharing Database
Autor: | Johann Jonsson, Eric Siskind, Sonia Pinto, Ernesto P. Molmenti, Leo Amodu, Meredith Akerman, Jorge Ortiz |
---|---|
Rok vydání: | 2018 |
Předmět: |
United Network for Organ Sharing
Adult Male Enteric drainage Tissue and Organ Procurement Adolescent Databases Factual Endocrinology Diabetes and Metabolism medicine.medical_treatment Urinary Bladder Kaplan-Meier Estimate 030230 surgery Pancreas transplantation computer.software_genre Exocrine secretion 03 medical and health sciences Young Adult 0302 clinical medicine Endocrinology Intestine Small Internal Medicine medicine Retrospective analysis Humans Drainage Bladder drainage Retrospective Studies Hepatology Database business.industry Graft Survival Middle Aged Kidney Transplantation surgical procedures operative medicine.anatomical_structure 030211 gastroenterology & hepatology Female Pancreas Transplantation Pancreas business computer |
Zdroj: | Pancreas. 47(5) |
ISSN: | 1536-4828 |
Popis: | OBJECTIVES The method for drainage of exocrine secretions in pancreas transplantation remains a matter of debate. Different methods have evolved over time. Most data on these methods are from single-center studies with small sample sizes. Larger studies have yielded conflicting results. METHODS Data from the United Network for Organ Sharing database on all adult subjects who received pancreas and kidney-pancreas transplants between 1996 and 2012 were analyzed (n = 19,934). Subjects were divided into 3 groups: enteric drainage with Roux-en-Y (n = 4308), enteric drainage without Roux-en-Y (n = 11,145), and bladder drainage (n = 4481). Primary end points were patient and graft survival at 1, 3, 5, 10, and 15 years. RESULTS There was a patient and graft survival advantage with enteric drainage without Roux-en-Y reconstruction compared with the other methods. This was consistent at 1, 3, 5, 10, and 15 years. CONCLUSIONS Our study demonstrated increased graft and patient survival when comparing enteric drainage of the transplanted pancreas without Roux-en-Y reconstruction to enteric drainage with Roux-en-Y and bladder drainage at 1, 3, 5, 10, and 15 years. Based on this study, we recommend enteric drainage without Roux-en-Y reconstruction as the method of choice in pancreas transplantation. |
Databáze: | OpenAIRE |
Externí odkaz: |