Major depressive disorder subtypes and depression symptoms in multiple sclerosis: What is different compared to the general population?

Autor: Andrew T. Chan, Marco Kaufmann, Stephanie Rodgers, Pasquale Calabrese, Jens Kuhle, Viktor von Wyl, Anke Salmen, Nina Steinemann, Vladeta Ajdacic-Gross, Chiara Zecca, Stefanie Müller, Christian P. Kamm, Zina-Mary Manjaly, Claudio Gobbi, Jürg Kesselring
Přispěvatelé: University of Zurich, Rodgers, Stephanie
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Adult
Male
medicine.medical_specialty
Multiple Sclerosis
Population
11549 Institute of Implementation Science in Health Care
610 Medicine & health
behavioral disciplines and activities
2738 Psychiatry and Mental Health
Young Adult
03 medical and health sciences
0302 clinical medicine
Multiple sclerosis
Depression
Subtypes
Internal medicine
Epidemiology
mental disorders
medicine
Humans
Registries
030212 general & internal medicine
education
Atypical depression
Depression (differential diagnoses)
Aged
Aged
80 and over
Depressive Disorder
Major
education.field_of_study
business.industry
3203 Clinical Psychology
10060 Epidemiology
Biostatistics and Prevention Institute (EBPI)
Middle Aged
medicine.disease
Latent class model
Diagnostic and Statistical Manual of Mental Disorders
Psychiatry and Mental health
Clinical Psychology
10054 Clinic for Psychiatry
Psychotherapy
and Psychosomatics
Case-Control Studies
Major depressive disorder
Female
business
Switzerland
030217 neurology & neurosurgery
Psychopathology
Zdroj: Journal of Psychosomatic Research, 144
Rodgers, Stephanie; Calabrese, Pasquale; Ajdacic-Gross, Vladeta; Steinemann, Nina; Kaufmann, Marco; Salmen, Anke; Manjaly, Zina-Mary; Kesselring, Jürg; Kamm, Christian P; Kuhle, Jens; Chan, Andrew; Gobbi, Claudio; Zecca, Chiara; Müller, Stefanie; von Wyl, Viktor (2021). Major depressive disorder subtypes and depression symptoms in multiple sclerosis: What is different compared to the general population? Journal of psychosomatic research, 144, p. 110402. Elsevier 10.1016/j.jpsychores.2021.110402
ISSN: 0022-3999
DOI: 10.1016/j.jpsychores.2021.110402
Popis: Objective: To compare and characterize major depressive disorder (MDD) subtypes (i.e., pure atypical, pure melancholic and mixed atypical-melancholic) and depression symptoms in persons with multiple sclerosis (PwMS) with persons without MS (Pw/oMS) fulfilling the DSM-5 criteria for a past 12-month MDD. Methods: MDD in PwMS (n = 92) from the Swiss Multiple Sclerosis Registry was compared with Pw/oMS (n = 277) from a Swiss community-based study. Epidemiological MDD diagnoses were based on the Mini-SPIKE (shortened form of the Structured Psychopathological Interview and Rating of the Social Consequences for Epidemiology). Logistic and multinomial regression analyses (adjusted for sex, age, civil status, depression and severity) were computed for comparisons and characterization. Latent class analysis (LCA) was conducted to empirically identify depression subtypes in PwMS. Results: PwMS had a higher risk for the mixed atypical-melancholic MDD subtype (OR = 2.22, 95% CI = 1.03–4.80) compared to Pw/oMS. MDD in PwMS was specifically characterized by a higher risk of the two somatic atypical depression symptoms ‘weight gain’ (OR = 6.91, 95% CI = 2.20–21.70) and ‘leaden paralysis’ (OR = 3.03, 95% CI = 1.35–6.82) and the symptom ‘irritable/angry’ (OR = 3.18, 95% CI = 1.08–9.39). Conclusions: MDD in PwMS was characterized by a higher risk for specific somatic atypical depression symptoms and the mixed atypical-melancholic MDD subtype. The pure atypical MDD subtype, however, did not differentiate between PwMS and Pw/oMS. Given the high phenomenological overlap with MS symptoms, the mixed atypical-melancholic MDD subtype represents a particular diagnostic challenge. © 2021 The Authors
Journal of psychosomatic research, 144
ISSN:0022-3999
Databáze: OpenAIRE
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