Aging restricts the ability of mesenchymal stem cells to promote the generation of oligodendrocytes during remyelination

Autor: Luis Federico Bátiz, Sebastien Couillard-Despres, Eleni Priglinger, Patrick Küry, Andreas Traweger, Maria Elena Silva, Robin J.M. Franklin, Richard Greil, Francisco J. Rivera, Chao Zhao, Ludwig Aigner, Martina Feichtner, Roman Wodnar, Ginez A. Gonzalez, Anna O’Sullivan, Alerie Guzman de la Fuente, Simona Lange, Janusz J. Jadasz, Herbert Tempfer, Oihana Errea, Pasquale Romanelli, Gabriele Brachtl
Přispěvatelé: Rivera, Francisco J [0000-0001-7895-6318], de la Fuente, Alerie G [0000-0001-8366-4969], Zhao, Chao [0000-0003-1144-1621], Silva, Maria E [0000-0001-6236-7180], Gonzalez, Ginez A [0000-0002-2146-9655], Priglinger, Eleni [0000-0002-1484-0444], Romanelli, Pasquale [0000-0003-0874-6918], Jadasz, Janusz J [0000-0002-5505-4570], Traweger, Andreas [0000-0002-0220-4766], Bátiz, Luis F [0000-0002-3043-8797], Küry, Patrick [0000-0002-2654-1126], Couillard-Despres, Sebastien [0000-0002-8486-6412], Franklin, Robin JM [0000-0001-6522-2104], Aigner, Ludwig [0000-0002-1653-8046], Apollo - University of Cambridge Repository
Jazyk: angličtina
Rok vydání: 2019
Předmět:
0301 basic medicine
Male
Oligodendroglia/physiology
Aging
CNS demyelination
oligodendrocytes
Biology
Demyelinating Diseases/physiopathology
multiple sclerosis
Neuroprotection
Cell therapy
Rats
Sprague-Dawley
Tissue Culture Techniques
03 medical and health sciences
Cellular and Molecular Neuroscience
0302 clinical medicine
Demyelinating disease
medicine
Animals
Progenitor cell
Remyelination
Research Articles
Cells
Cultured
mesenchymal stem cells
CNS stem and progenitor cells
Mesenchymal stem cell
Oligodendrocyte differentiation
Mesenchymal Stem Cells/physiology
medicine.disease
Aging/physiology
Rats
Inbred F344
3. Good health
Cell biology
Oligodendroglia
Disease Models
Animal
030104 developmental biology
medicine.anatomical_structure
remyelination
Neurology
Remyelination/physiology
Female
cell therapy
030217 neurology & neurosurgery
Research Article
Demyelinating Diseases
Zdroj: Rivera, F J, de la Fuente, A G, Zhao, C, Silva, M E, Gonzalez, G A, Wodnar, R, Feichtner, M, Lange, S, Errea, O, Priglinger, E, O'Sullivan, A, Romanelli, P, Jadasz, J J, Brachtl, G, Greil, R, Tempfer, H, Traweger, A, Bátiz, L F, Küry, P, Couillard-Despres, S, Franklin, R J M & Aigner, L 2019, ' Aging restricts the ability of mesenchymal stem cells to promote the generation of oligodendrocytes during remyelination ', Glia, vol. 67, no. 8, pp. 1510-1525 . https://doi.org/10.1002/glia.23624
Glia
DOI: 10.1002/glia.23624
Popis: Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS) that leads to severe neurological deficits. Due to their immunomodulatory and neuroprotective activities and their ability to promote the generation of oligodendrocytes, mesenchymal stem cells (MSCs) are currently being developed for autologous cell therapy in MS. As aging reduces the regenerative capacity of all tissues, it is of relevance to investigate whether MSCs retain their pro‐oligodendrogenic activity with increasing age. We demonstrate that MSCs derived from aged rats have a reduced capacity to induce oligodendrocyte differentiation of adult CNS stem/progenitor cells. Aging also abolished the ability of MSCs to enhance the generation of myelin‐like sheaths in demyelinated cerebellar slice cultures. Finally, in a rat model for CNS demyelination, aging suppressed the capability of systemically transplanted MSCs to boost oligodendrocyte progenitor cell (OPC) differentiation during remyelination. Thus, aging restricts the ability of MSCs to support the generation of oligodendrocytes and consequently inhibits their capacity to enhance the generation of myelin‐like sheaths. These findings may impact on the design of therapies using autologous MSCs in older MS patients.
Databáze: OpenAIRE
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