A randomized placebo-controlled trial of the effect of coffee consumption on insulin sensitivity: Design and baseline characteristics of the Coffee for METabolic Health (COMETH) study
| Autor: | Shahram Emady-Azar, Rob M. van Dam, Eric Yin Hao Khoo, Sharna Si-Ying Seah, Chieh Jason Chou, Salome A. Rebello, Zoey Tay, Derrick Johnston Alperet, Christian Darimont, Bee Choo Tai |
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| Jazyk: | angličtina |
| Předmět: |
medicine.medical_specialty
Placebo-controlled study 030209 endocrinology & metabolism Type 2 diabetes Overweight Lower risk Coffee Article 03 medical and health sciences 0302 clinical medicine Insulin resistance Internal medicine Diabetes mellitus medicine 030212 general & internal medicine Pharmacology lcsh:R5-920 business.industry Hyperinsulinemic euglycemic clamp Type 2 Diabetes Mellitus General Medicine medicine.disease Insulin sensitivity Endocrinology Non-insulin dependent diabetes mellitus medicine.symptom lcsh:Medicine (General) business Cohort study |
| Zdroj: | Contemporary Clinical Trials Communications, Vol 4, Iss C, Pp 105-117 (2016) Contemporary Clinical Trials Communications |
| ISSN: | 2451-8654 0173-8399 |
| DOI: | 10.1016/j.conctc.2016.06.013 |
| Popis: | Background: Coffee consumption has been consistently associated with a lower risk of type 2 diabetes mellitus in cohort studies. In addition, coffee components increased insulin sensitivity in animal models. However, data from intervention studies on the effect of coffee consumption on glucose metabolism have been limited by small sample sizes, lack of blinding, short follow-up duration and the use of surrogate indices of insulin sensitivity. We designed the Coffee for Metabolic Health (COMETH) study to evaluate the effect of coffee consumption on insulin sensitivity. Methodology: The COMETH study is a double-blind randomized placebo-controlled 24-week trial. Participants were overweight, male and female habitual coffee consumers who were of Chinese, Malay and Asian-Indian ethnicity. We excluded smokers, persons with diabetes, and persons with low insulin resistance (HOMA-IR |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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