Improving affinity of imprinted monolithic polymer prepared in deep eutectic solvent by metallic pivot
| Autor: | Ze-Hui Wei, Li-Na Mu, Zhao-Sheng Liu, Yan-Ping Huang, Xuan Sun |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Ethylene Glycol
Monolithic HPLC column Polymers 010402 general chemistry 01 natural sciences Biochemistry Chemistry Techniques Analytical Analytical Chemistry Polymerization Molecular Imprinting chemistry.chemical_compound chemistry.chemical_classification Chromatography Ethanol 010401 analytical chemistry Organic Chemistry Molecularly imprinted polymer General Medicine Polymer Cetirizine 0104 chemical sciences Deep eutectic solvent Solvent chemistry Chemical engineering Metals Ionic liquid Solvents Ethylene glycol |
| Zdroj: | Journal of chromatography. A. 1602 |
| ISSN: | 1873-3778 |
| Popis: | One of the major drawbacks of conventional molecularly imprinted polymers (MIPs) is the requirements of volatility porogenic solvent during polymerization. To overcome the default, MIP based on deep eutectic solvent (DES, a new type of green designer solvents) has been synthesized successfully. To improve the affinity of the MIP based on DES, in this work, a strategy of metallic pivot was suggested in the first time to prepare a highly selective MIP monolithic column. A cetirizine-imprinted polymer was prepared in a DES-based porogen system composed of choline chloride/ ethylene glycol (ChCl-EG) in the presence of Co(Ac)2 as metallic pivot. The resulting DES- Co2+-MIP monolith had 23.5 times higher imprinting factor than the Co2+-free MIP monolith. The characterization of polymers indicated that DES was one of the primary factor influencing the MIP morphology and pore structure. Compared with previous metal-mediated and ionic liquid-based imprinted polymers, the introduction of DES as a porogen in polymerization led to higher imprinting factor (approximately 2.9 - 17.1 times). In addition, the resulting DES-Co2+-MIP can be used as an adsorbent for extraction of cetirizine from ethanol solution with the recoveries of 97.8%. As a conclusion, the metallic pivot is a rather valuable strategy for the synthesis of DES-based MIP monolith with high selectivity. |
| Databáze: | OpenAIRE |
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