Diarrhea with epidermal growth factor receptor tyrosine kinase inhibitors in cancer patients: A meta-analysis of randomized controlled trials
| Autor: | Jing Li, Jian Gu |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Diarrhea
0301 basic medicine medicine.medical_specialty MEDLINE Subgroup analysis law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Neoplasms Internal medicine medicine Humans Protein Kinase Inhibitors Randomized Controlled Trials as Topic business.industry Cancer Hematology Prognosis medicine.disease ErbB Receptors 030104 developmental biology Increased risk Oncology 030220 oncology & carcinogenesis Meta-analysis medicine.symptom business Epidermal growth factor receptor tyrosine kinase |
| Zdroj: | Critical Reviews in Oncology/Hematology. 134:31-38 |
| ISSN: | 1040-8428 |
| Popis: | We performed an meta-analysis to fully investigate the diarrhea of EGFR-TKIs in cancer patients. The relevant studies of the randomized controlled trials (RCTs) in cancer patients treated with EGFR-TKIs were retrieved and the systematic evaluation was conducted. EMBASE, MEDLINE, and PubMed were searched for articles published till August 2017. The relevant RCTs in cancer patients treated with EGFR-TKIs were retrieved and the systematic evaluation was conducted. Twenty-four RCTs and 13,748 patients were included. The current analysis suggested that the use of EGFR-TKIs increased the risk of all-grade diarrhea (RR 3.45; 95%CI, 2.94-4.06; p＜0.00001) and high-grade (≥grade 3) diarrhea (RR 8.22；95%CI, 6.02-11.23; p＜0.00001). On subgroup analysis, the risk of all-grade and high-grade diarrhea varied significantly within drug type. The risk of all-grade diarrhea varied significantly according to cancer type, whereas the risk of high-grade diarrhea did not. The risk of all-grade and high-grade diarrhea did not varied significantly based on treatment line, treatment duration and median age. The available data suggested that the use of EGFR-TKIs is associated with a significantly increased risk of diarrhea in cancer patients. |
| Databáze: | OpenAIRE |
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