Effects of L-type calcium channel antagonists on the serotonin-depleting actions of MDMA in rats
| Autor: | Suhue Wei, Jennifer A. Clikeman, Larry D. Calder, Kevin T. Finnegan, Ralph Karler |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Male
Serotonin Nifedipine N-Methyl-3 4-methylenedioxyamphetamine chemistry.chemical_element Calcium Pharmacology Hippocampus Methamphetamine Rats Sprague-Dawley Seizures medicine Animals L-type calcium channel Molecular Biology Flunarizine 3 4-Methylenedioxyamphetamine Brain Chemistry Cerebral Cortex General Neuroscience Calcium channel MDMA Calcium Channel Blockers Rats chemistry Verapamil Haloperidol Neurology (clinical) Stereotyped Behavior Developmental Biology medicine.drug |
| Zdroj: | Brain research. 603(1) |
| ISSN: | 0006-8993 |
| Popis: | The calcium channel antagonists verapamil nifedipine and flunarizine all increased the threshold for convulsions induced by N -methyl- d -aspartate in rats. By contrast, only flunarizine blocked the long-term serotonin-depleting effects of 3,4-methylenedioxymethamphetamine. Flunarizine was also the only drug that antagonized methamphetamine-induced stereotypy. These findings suggest that calcium influx through L-type channels does not participate in the neurotoxic mechanism of MDMA, and tha t the neuroprotective actions of flunarizine are probably related to its anti-dopaminergic activity. |
| Databáze: | OpenAIRE |
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