A novel translocation involving chromosomes 2, 9, 14, and 22 in chronic myeloid leukemia
| Autor: | Kazuyasu Endo, Junichi Kameoka, Keishi Abe, Kuniaki Meguro, Osamu Fukuhara, Tomohiro Sugawara, Akiyoshi Sato, Tomoaki Shishido |
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| Rok vydání: | 1995 |
| Předmět: |
Male
Cancer Research Chromosomes Human Pair 22 Chromosomal translocation Biology Translocation Genetic Leukemia Myelogenous Chronic BCR-ABL Positive hemic and lymphatic diseases Genetics medicine Humans Molecular Biology Gene Southern blot Chromosomes Human Pair 14 breakpoint cluster region Myeloid leukemia Karyotype Middle Aged medicine.disease Molecular biology Chromosome Banding medicine.anatomical_structure Chromosomes Human Pair 2 Karyotyping Immunology Bone marrow Chromosomes Human Pair 9 Chronic myelogenous leukemia |
| Zdroj: | Cancer Genetics and Cytogenetics. 80:155-157 |
| ISSN: | 0165-4608 |
| DOI: | 10.1016/0165-4608(94)00163-6 |
| Popis: | A 46-year-old man with chronic myelogenous leukemia was found to have a new complex translocation. In chronic phase, all of the bone marrow cells had a rearrangement of a t(2;9;14;22) (p21;q34;q32;q11). Southern blot analysis of leukocyte DNA revealed rearrangement of the breakpoint cluster region (bcr) within the 5.8-Kb bcr. The patient eventually died in blast crisis 28 months later. The cytogenetic findings of bone marrow cells showed a 46,XY,t(2;9;14;22)(p21;q34;q32;qll),add(lp),del(3q) karyotype in blast crisis. |
| Databáze: | OpenAIRE |
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