Treatment approach to type 2 diabetes: past, present and future
| Autor: | Kristina Blaslov, Ivana Pavlić Renar, Ivan Kruljac, Fran Stjepan Naranđa |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism medicine.medical_treatment 030209 endocrinology & metabolism Review Disease Type 2 diabetes 03 medical and health sciences Hypoglycaemic agents 0302 clinical medicine Insulin resistance Pharmacotherapy Diabetes mellitus Type 2 diabetes mellitus Internal Medicine medicine Hyperglycaemia 030212 general & internal medicine Metabolic disease Intensive care medicine Physical activity business.industry Insulin Type 2 Diabetes Mellitus medicine.disease business |
| Zdroj: | World Journal of Diabetes |
| DOI: | 10.4239/wjd.v9.i12.209 |
| Popis: | Type 2 diabetes mellitus (DM) is a lifelong metabolic disease, characterized by hyperglycaemia which gradually leads to the development and progression of vascular complications. It is recognized as a global burden disease, with substantial consequences on human health (fatality) as well as on health-care system costs. This review focuses on the topic of historical discovery and understanding the complexity of the disease in the field of pathophysiology, as well as development of the pharmacotherapy beyond insulin. The complex interplay of insulin secretion and insulin resistance developed from previously known "ominous triumvirate" to "ominous octet" indicate the implication of multiple organs in glucose metabolism. The pharmacological approach has progressed from biguanides to a wide spectrum of medications that seem to provide a beneficial effect on the cardiovascular system. Despite this, we are still not achieving the target treatment goals. Thus, the future should bring novel antidiabetic drug classes capable of acting on several levels simultaneously. In conclusion, given the raising burden of type 2 DM, the best present strategy that could contribute the most to the reduction of morbidity and mortality should be focused on primary prevention. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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