Anti-hyperglycaemic effect of labdane diterpenes isolated from the rhizome of Amomum maximum Roxb., an edible plant in Southwest China
| Autor: | Qing-Hua Huang, Qing-Fei Fan, Li-Ning Wang, Ya-jun Li, Chuan-li Lu, Jun-jia Chen |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Traditional medicine
010405 organic chemistry α glucosidase Organic Chemistry Plant Science Biology 01 natural sciences Biochemistry 0104 chemical sciences Analytical Chemistry Southeast asia Rhizome Anti hyperglycaemic Labdane 010404 medicinal & biomolecular chemistry chemistry.chemical_compound chemistry Amomum maximum |
| Zdroj: | Natural Product Research. 36:2570-2574 |
| ISSN: | 1478-6427 1478-6419 |
| DOI: | 10.1080/14786419.2021.1903006 |
| Popis: | Amomum maximum Roxb. rhizome is a fork medicine mainly used in South and Southeast Asia. In present study, the hypoglycaemic effects of the ethanolic extract of A. maximum rhizome were demonstrated both on α-glucosidase assay in vitro and streptozotocin (STZ)-induced postprandial hyperglycaemia in mice. Furthermore, six labdane diterpenes, amoxanthin A (1), ottensinin (2), coronarin D (3), coronarin D methyl ether (4), isocoronarin D (5), and zerumin (6), were isolated from its ethyl acetate sub-fraction with the guidance of α-glucosidase inhibitory activity. Among these compounds, 2 and 6 exhibited significant inhibitory effect on α-glucosidase, as well as on STZ-induced high postprandial blood glucose levels in mice. Additionally, molecular docking analysis revealed that 2 and 6 could firmly bind to the active sites of α-glucosidase. These results suggest that compounds 2 and 6 are the main anti-hyperglycaemic agents present in A. maximum, which may demonstrate potential beneficial effects in diabetes management. |
| Databáze: | OpenAIRE |
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