Volumetric brain analysis as a predictor of a worse cognitive outcome in Parkinson's disease
| Autor: | Ana Lara Malak, Helenice Charchat-Fichman, Denise Vieira Greca, Marcelo Adachi, Luiz Felipe Rocha Vasconcellos, João Santos Pereira, Manuela Cruz |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Parkinson's disease Neuropsychological Tests 03 medical and health sciences 0302 clinical medicine Physical medicine and rehabilitation Neuroimaging Image Processing Computer-Assisted medicine Humans Effects of sleep deprivation on cognitive performance Neuropsychological assessment Cognitive decline Biological Psychiatry Brain Mapping medicine.diagnostic_test business.industry Neuropsychology Brain Parkinson Disease Cognition Middle Aged medicine.disease Magnetic Resonance Imaging Psychiatry and Mental health 030104 developmental biology Inclusion and exclusion criteria Female Cognition Disorders business 030217 neurology & neurosurgery Follow-Up Studies |
| Zdroj: | Journal of Psychiatric Research. 102:254-260 |
| ISSN: | 0022-3956 |
| Popis: | Cognitive impairment in Parkinson's disease (PD) results in significant morbidity and mortality being early diagnosis essential. Identification of patients who are at higher risk of developing cognitive impairment based only on clinical data is not sufficient. To this end, magnetic resonance imaging (MRI) with automatic segmentation, such as FreeSurfer, could be a useful tool with high accuracy because it has histological validation. Objectives The objective of this study was to evaluate clinical, neuropsychological and FreeSurfer variables that may be related to worse cognitive outcomes over 18 months in PD patients compared with controls. Methods PD patients were recruited according to established inclusion and exclusion criteria as well individuals without any neurological or psychiatric diagnosis and were submitted to the same protocol: neurological, neuropsychological and neuroimaging evaluations. After 18 months, the study subjects were reassessed by neurological and neuropsychological evaluations. Results Of 171 individuals selected for first evaluation, 96 concluded the study during 18-month follow-up. The PD group presented worse performance in the neuropsychological assessment during both the initial and final evaluations. The results obtained by FreeSurfer revealed a significant reduction (unilateral or bilateral) in the volume of thalamus, caudate nucleus, putamen, hippocampus, amygdala, accumbens, corpus callosum and cerebral gray matter in the PD group. A worse cognitive outcome was more prevalent in the PD group. Conclusions Worse cognitive performance documented by neuropsychological assessment in the PD group was correlated with reduced volume of several structures by FreeSurfer analysis and may be a biomarker of cognitive decline. |
| Databáze: | OpenAIRE |
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