Construction and evaluation of red blood cells-based drug delivery system for chemo-photothermal therapy
| Autor: | Binbin Chen, Jingru Huang, Chen Wang, Yan Zhang, Hongxin Jia |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Drug
Erythrocytes Photothermal Therapy media_common.quotation_subject 02 engineering and technology 01 natural sciences chemistry.chemical_compound Drug Delivery Systems Colloid and Surface Chemistry Cell Line Tumor hemic and lymphatic diseases 0103 physical sciences medicine Doxorubicin Physical and Theoretical Chemistry media_common 010304 chemical physics Photothermal effect Cancer hemic and immune systems Hyperthermia Induced Surfaces and Interfaces General Medicine Phototherapy Photothermal therapy 021001 nanoscience & nanotechnology medicine.disease Drug Liberation Pharmaceutical Preparations chemistry Drug delivery Cancer cell Nanoparticles 0210 nano-technology Indocyanine green circulatory and respiratory physiology Biotechnology Biomedical engineering medicine.drug |
| Zdroj: | Colloids and Surfaces B: Biointerfaces. 204:111789 |
| ISSN: | 0927-7765 |
| Popis: | In this study, a novel tumor-targeting drug delivery system (DDS) based on red blood cells (RBCs) were fabricated for combinational chemo-phototherapy against cancer. Cyclic peptide (cRGD) and indocyanine green (ICG) were applied to the surface of RBCs to increase the targeting and photothermal effect, respectively. Doxorubicin (DOX) as a model drug was loaded into RBCs by the hypotonic dialysis method. A series of tests have been carried out to evaluate the RBCs-based DDS and these tasks include physicochemical properties, cellular uptake, targeting ability, and combination therapeutic efficiency. As a result, the DOX was successfully loaded into RBCs and the drug loading amount was 0.84 ± 0.09 mg/mL. There was no significant change of particle size after surface modification of RBCs. The RBCs-based DDS could target to the surface of cancer cells, which delivery DOX to the lesions efficiently and accurately. Meanwhile, due to the combined treatment effect, the RBCs-based DDS can effectively inhibit tumor growth. The RBCs-based DDS constructed in this research may have promising applications in cancer therapy due to their highly synergistic efficient therapy and to investigate its possibility for tumor therapy. |
| Databáze: | OpenAIRE |
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