The impact of fresh frozen plasma vs coagulation factor concentrates on morbidity and mortality in trauma-associated haemorrhage and massive transfusion
| Autor: | Isabella Westermann, Rene Attal, Ulrike Nienaber, Herbert Schöchl, Robert Breitkopf, Marc Maegele, Petra Innerhofer |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Resuscitation medicine.medical_specialty Blood transfusion medicine.medical_treatment Hemorrhage Fibrinogen Plasma Young Adult Injury Severity Score Germany Blood plasma medicine Coagulopathy Humans Blood Transfusion Hospital Mortality Prospective Studies Prospective cohort study General Environmental Science business.industry Multiple Trauma Middle Aged medicine.disease Blood Coagulation Factors Surgery Treatment Outcome Anesthesia Austria General Earth and Planetary Sciences Female Fresh frozen plasma business medicine.drug |
| Zdroj: | Injury. 42(7) |
| ISSN: | 1879-0267 |
| Popis: | A B S T R A C T Introduction: Clinical observations together with recent research highlighted the role of coagulopathy in acute trauma care and early aggressive treatment has been shown to reduce mortality. Methods: Datasets from severely injured and bleeding patients with established coagulopathy upon emergency room (ER) arrival from two retrospective trauma databases, (i) TR-DGU (Germany) and (ii) Innsbruck Trauma Databank/ITB (Austria), that had received two different strategies of coagulopathy management during initial resuscitation, (i) fresh frozen plasma (FFP) without coagulation factor concentrates, and (ii) coagulation factor concentrates (fibrinogen and/or prothrombin complex concentrates) without FFP, were compared for morbidity, mortality and transfusion requirements using a matched-pair analysis approach. Results: There were no major differences in basic characteristics and physiological variables upon ER admission between the two cohorts that were matched. ITB patients had received substantially less packed red blood cell (pRBC) concentrates within the first 6 h after admission (median 1.0 (IQR25-75 0-3) vs 7.5 (IQR25-75 4-12) units; p < 0.005) and the first 24 h as compared to TR-DGU patients (median 3 (IQR25-75 0-5) vs 12.5 (8-20) units; p < 0.005). Overall mortality was comparable between both groups whilst the frequency for multi organ failure was significantly lower within the group that had received coagulation factor concentrates exclusively and no FFP during initial resuscitation (n = 3 vs n = 15; p = 0.015). This translated into trends towards reduced days on ventilator whilst on ICU and shorter overall in-hospital length of stays (LOS). Conclusion: Although there was no difference in overall mortality between both groups, significant differences with regard to morbidity and need for allogenic transfusion provide a signal supporting the management of acute post-traumatic coagulopathy with coagulation factor concentrates rather than with traditional FFP transfusions. Prospective and randomised clinical trials with sufficient patient numbers based upon this strategy are advocated. 2011 Published by Elsevier Ltd. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect