Parasympathetic Response to Acute Stress is Attenuated in Young Zucker Obese Rats
| Autor: | David R. Brown, Sheng-Gang Li, Re'Gie Smith, Yasser El-Wazir, David C. Randall, Dennis L. Silcox |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Bradycardia
Atropine Nitroprusside medicine.medical_specialty Adrenergic beta-Antagonists Conditioning Classical Blood Pressure Propranolol Muscarinic Antagonists Baroreflex Article Cellular and Molecular Neuroscience Phenylephrine Heart Rate Parasympathetic Nervous System Stress Physiological Internal medicine Heart rate Reflex Medicine Animals Nitric Oxide Donors Obesity Sympathomimetics Endocrine and Autonomic Systems business.industry Body Weight Electric Stimulation Rats Rats Zucker Blood pressure Endocrinology Injections Intravenous Neurology (clinical) Sodium nitroprusside medicine.symptom business medicine.drug |
| Popis: | We compared arterial blood pressure (BP) and heart rate (HR) control in 9- to 11-week old obese Zucker rats (n=10; weight=452+/-45 g, average+/-SD) to age-matched, lean Zucker animals (n=13; weight=280+/-46 g). BP was measured by indwelling catheter. Baseline pressure was 113.1+/-7.0 mm Hg in the lean vs. 111.7+/-5.6 in the obese rats (NS). Baseline HR was 413+/-43 in the lean vs. 422+/-22 bpm in the obese animals (NS). Rats were classically conditioned by following a 15-second tone (CS+) with a 0.5-second tail shock. There were no between-group differences in the BP response to CS+. Conversely, heart rate (HR) decreased significantly (p |
| Databáze: | OpenAIRE |
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