Low-dose rituximab is poorly effective in patients with primary membranous nephropathy
| Autor: | Piergiorgio Messa, Selena Longhi, Beniamina Gallelli, Renato Alberto Sinico, Lucia Del Vecchio, Gabriella Moroni, Federica Depetri, Elisa Giglio, Francesca Raffiotta, Marco D'Amico, Francesca Brunini, Antonella Radice |
|---|---|
| Přispěvatelé: | Moroni, G, Depetri, F, Del Vecchio, L, Gallelli, B, Raffiotta, F, Giglio, E, Brunini, F, D'Amico, M, Longhi, S, Radice, A, Messa, P, Sinico, R |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Nephrotic Syndrome 030232 urology & nephrology Urology Renal function 030204 cardiovascular system & hematology Glomerulonephritis Membranous 03 medical and health sciences Young Adult 0302 clinical medicine Antineoplastic Agents Immunological Membranous nephropathy Medicine Humans In patient Dosing Prospective Studies Young adult Prospective cohort study Aged Transplantation business.industry Receptors Phospholipase A2 Remission Induction membranous nephropathy Middle Aged medicine.disease Treatment Outcome Nephrology Rituximab Female business Nephrotic syndrome Biomarkers medicine.drug |
| Zdroj: | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 32(10) |
| ISSN: | 1460-2385 |
| Popis: | Background The optimal dosing and the efficacy of rituximab for primary membranous nephropathy (PMN) has not been established. This multicentric prospective study evaluates the efficacy and safety of low-dose rituximab (RTX) therapy in patients with PMN in clinical practice. Methods Thirty-four consecutive patients with PMN and nephrotic syndrome were included and received RTX (375 mg/m 2) once (18 patients) or twice (16 patients). RTX was the first-line therapy for 19 (56%) and the second line for 15 (44%) patients. All patients were followed for 12 months after RTX and 24 for at least 18 months (mean 23.9 ± 18.6 months). Results At 12 months, 5 patients (14.7%) achieved complete response, 10 (29.4%) partial and 19 (55.8%) no response. Response occurred '1/46 months after RTX. At 24 months, the clinical situation was unchanged: two non-responders achieved partial response and two responders relapsed. Responders had significantly higher baseline GFR and lower anti-PLA2R antibodies compared with non-responders. Outcome was similar between one or two doses of RTX (non-responders 55.5 versus 56%, respectively) and between patients who had received previous therapy versus those receiving RTX as first-line therapy (non-responders 40 versus 68%, respectively). In the 15 patients already treated, the response to RTX was comparable to that of previous therapies. Conclusion Low-dose RTX obtains remission in |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|