Effectiveness of drug use evaluation and antibiotic authorization on patients' clinical outcomes, antibiotic consumption, and antibiotic expenditures
| Autor: | Patama Sutha, Pinyo Rattanaumpawan, Visanu Thamlikitkul |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty Imipenem Epidemiology medicine.drug_class Antibiotics Meropenem Tazobactam Drug Utilization Review medicine Humans Medical prescription Intensive care medicine Aged Antibacterial agent Aged 80 and over business.industry Health Policy Public Health Environmental and Occupational Health Bacterial Infections Middle Aged Thailand Drug Utilization Organizational Policy Anti-Bacterial Agents Infectious Diseases Emergency medicine Piperacillin/tazobactam Female Health Services Research business Piperacillin medicine.drug |
| Zdroj: | American Journal of Infection Control. 38:38-43 |
| ISSN: | 0196-6553 |
| Popis: | Piperacillin/tazobactam, imipenem, and meropenem were inappropriately used in 50% of hospitalized patients at Siriraj Hospital. Siriraj Hospital administrators implemented drug use evaluation (DUE) and antibiotic authorization for the aforementioned antibiotics beginning in August 2007. The objective of the study was to determine the effectiveness of antibiotic authorization on patients' clinical outcomes, antibiotic consumption, and antibiotic expenditures.Hospitalized patients who were prescribed piperacillin/tazobactam, imipenem, or meropenem from August to November 2007 were randomly allocated to antibiotic authorization group and no-authorization group. The data on clinical outcomes, antibiotic consumption, and antibiotic expenditures of the patients who received and who did not receive antibiotic authorization were compared.The patients who received antibiotic authorization (512 prescriptions) had more favorable clinical outcomes (68.9% vs 60.5%, respectively, P.01), shorter duration of target antibiotics (7.5 days vs 9.3 days, respectively, P.01), shorter duration of all antibiotics (12.7 days vs 16.4 days, respectively, P.01), and lower mortality because of infections (29.4% vs 35.4%, respectively, P=.05) than those who did not receive antibiotic authorization (516 prescriptions). The costs of target antibiotics and all antibiotics in the authorization group were much less than those in the no-authorization group. The annual antibiotic cost savings from DUE and antibiotic authorization requirement could be extrapolated to US $862,704.DUE and antibiotic authorization are effective strategies in reducing antibiotic consumption and antibiotic expenditures without compromising the patients' clinical outcomes. |
| Databáze: | OpenAIRE |
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