Regulation of inflammation by selenium and selenoproteins: impact on eicosanoid biosynthesis

Autor: S.A. Mattmiller, Lorraine M. Sordillo, Bradley A. Carlson
Rok vydání: 2013
Předmět:
TXB2
thromboxane B2
Endocrinology
Diabetes and Metabolism
AA
arachidonic acid
GPX4
Bioinformatics
medicine.disease_cause
ASK-1
apoptosis signal-regulating kinase 1
H-PGDS
haematopoietic PGD2 synthase
HO-1
haeme oxygenase-1
Trx
thioredoxin
Selenoproteins
LOX
lipoxygenase
chemistry.chemical_classification
Leukotriene
Nutrition and Dietetics
GPx
glutathione peroxidase
Eicosanoid metabolism
Nutritional Immunology
15-HPETE
15-hydroperoxyeicosatetraenoic acid
Human morbidity
MAPK
itogen-activated protein kinase
LPS
lipopolysaccharide
ppm
parts per million
Sepp1
selenoprotein P plasma 1
medicine.symptom
Essential nutrient
GPx4
glutathione peroxidase-4
TrxR
thioredoxin reductase
LT
leukotriene
Inflammation
Biology
Selenium
COX
cyclo-oxygenase
ROS
reactive oxygen species
LTA4H
leukotriene A4 hydrolase
medicine
LA
linoleic acid
TX
thromboxane
15-HETE
15(S)-hydroxy-(5Z
8Z
11Z
13E)-eicosatetraenoic acid
HPODE
hydroperoxyoctadecadienoic acid
FAHP
fatty acid hydroperoxide
15d-PGJ2
15-deoxy-Δ12
14PGJ2
HPETE
hydroperoxyeicosatetraenoic acid
Eicosanoid biosynthesis
chemistry
Immunology
Cyclo-oxygenase
Oxidative stress
Food Science
Zdroj: Journal of Nutritional Science
ISSN: 2048-6790
DOI: 10.1017/jns.2013.17
Popis: Uncontrolled inflammation is a contributing factor to many leading causes of human morbidity and mortality including atherosclerosis, cancer and diabetes. Se is an essential nutrient in the mammalian diet that has some anti-inflammatory properties and, at sufficient amounts in the diet, has been shown to be protective in various inflammatory-based disease models. More recently, Se has been shown to alter the expression of eicosanoids that orchestrate the initiation, magnitude and resolution of inflammation. Many of the health benefits of Se are thought to be due to antioxidant and redox-regulating properties of certain selenoproteins. The present review will discuss the existing evidence that supports the concept that optimal Se intake can mitigate dysfunctional inflammatory responses, in part, through the regulation of eicosanoid metabolism. The ability of selenoproteins to alter the biosynthesis of eicosanoids by reducing oxidative stress and/or by modifying redox-regulated signalling pathways also will be discussed. Based on the current literature, however, it is clear that more research is necessary to uncover the specific beneficial mechanisms behind the anti-inflammatory properties of selenoproteins and other Se metabolites, especially as related to eicosanoid biosynthesis. A better understanding of the mechanisms involved in Se-mediated regulation of host inflammatory responses may lead to the development of dietary intervention strategies that take optimal advantage of its biological potency.
Databáze: OpenAIRE
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