A de novo variant in the bovine ADAMTSL4 gene in an Original Braunvieh calf with congenital cataract
| Autor: | Häfliger, Irene M, Wolf‐Hofstetter, Sonja, Casola, Christina, Hetzel, Udo, Seefried, Franz R, Drögemüller, Cord |
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| Přispěvatelé: | University of Zurich, Drögemüller, Cord |
| Rok vydání: | 2022 |
| Předmět: |
genetic structures
Whole Genome Sequencing 630 Agriculture Mutation Missense Cattle Diseases 10184 Institute of Veterinary Pathology 610 Medicine & health General Medicine eye diseases Cataract Pedigree 1311 Genetics Genetics 590 Animals (Zoology) Animals 570 Life sciences biology Cattle Animal Science and Zoology 10090 Equine Department 1103 Animal Science and Zoology |
| Zdroj: | Häfliger, Irene M.; Wolf-Hofstetter, Sonja; Casola, Christina; Hetzel, Udo; Seefried, Franz R.; Drögemüller, Cord (2022). A de novo variant in the bovine ADAMTSL4 gene in an Original Braunvieh calf with congenital cataract. Animal genetics, 53(3), pp. 416-421. Wiley 10.1111/age.13178 |
| ISSN: | 1365-2052 0268-9146 |
| Popis: | Inherited forms of cataract are a heterogeneous group of eye disorders known in livestock species. Clinicopathological analysis of a single case of impaired vision in a newborn Original Braunvieh calf revealed nuclear cataract. Whole-genome sequencing of the parent-offspring trio revealed a de novo mutation of ADAMTSL4 in this case. The heterozygous p.Arg776His missense variant affects a conserved residue of the ADAMTSL4 gene that encodes a secreted glycoprotein expressed in the lens throughout embryonic development. In humans, ADAMTSL4 genetic variants cause recessively inherited forms of subluxation of the lens. Given that ADAMTSL4 is a functional candidate gene for inherited disorders of the lens, we suggest that heterozygosity for the identified missense variant may have caused the congenital cataract in the affected calf. Cattle populations should be monitored for unexplained cataract cases, with subsequent DNA sequencing a hypothesized pathogenic effect of heterozygous ADAMTSL4 variants could be confirmed. |
| Databáze: | OpenAIRE |
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