NTS catecholamine neurons mediate hypoglycemic hunger via medial hypothalamic feeding pathways
| Autor: | Tayfun Ates, Deniz Atasoy, İltan Aklan, İlknur Çoban, Witold Konopka, Huxing Cui, Nilufer Sayar Atasoy, Merve Öncül, Fulya Köksalar, Gizem Filiz, Iskalen Cansu Topcu, Karolina Hajdukiewicz, Utku Cebecioğlu, Muhammed Ikbal Alp, Pelin Dilsiz, Deborah R. Davis, Yavuz Yavuz, Kenji Saito, Bayram Yilmaz |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male NTS Catecholamine Neurons Physiology media_common.quotation_subject Hypothalamus Biology Article 03 medical and health sciences Mice 0302 clinical medicine Arcuate nucleus Orexigenic medicine Solitary Nucleus Animals Agouti-Related Protein Molecular Biology media_common Neurons Medial Hypothalamic Tyrosine hydroxylase Appetite Regulation digestive oral and skin physiology Solitary tract Appetite Cell Biology Hypoglycemia Mice Inbred C57BL 030104 developmental biology medicine.anatomical_structure nervous system Female Energy source Nucleus Neuroscience 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Cell Metab |
| Popis: | Glucose is the essential energy source for the brain, whose deficit, triggered by energy deprivation or therapeutic agents, can be fatal. Increased appetite is the key behavioral defense against hypoglycemia; however, the central pathways involved are not well understood. Here, we describe a glucoprivic feeding pathway by tyrosine hydroxylase (TH)-expressing neurons from nucleus of solitary tract (NTS), which project densely to the hypothalamus and elicit feeding through bidirectional adrenergic modulation of agouti-related peptide (AgRP)- and proopiomelanocortin (POMC)-expressing neurons. Acute chemogenetic inhibition of arcuate nucleus (ARC)-projecting NTSTH neurons or their target, AgRP neurons, impaired glucoprivic feeding induced by 2-Deoxy-D-glucose (2DG) injection. Neuroanatomical tracing results suggested that ARC-projecting orexigenic NTSTH neurons are largely distinct from neighboring catecholamine neurons projecting to parabrachial nucleus (PBN) that promotes satiety. Collectively, we describe a circuit organization in which an ascending pathway from brainstem stimulates appetite through key hunger neurons in the hypothalamus in response to hypoglycemia. EMBO IG FOEDRC |
| Databáze: | OpenAIRE |
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