Cis-platinum(II) diamine dichloride causes mutation, transformation, and sister-chromatid exchanges in cultured mammalian cells
| Autor: | N. C. Popescu, Joseph A. DiPaolo, D. Turnbull, B.C. Myhr |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Drug Evaluation
Preclinical Hamster Toxicology medicine.disease_cause Chinese hamster Chromosomes Cell Line Cricetinae Genetics medicine Sister chromatids Animals Crossing Over Genetic Carcinogen Chromosome Aberrations Mutation biology Dose-Response Relationship Drug Mesocricetus Chromosome Embryo biology.organism_classification Embryo Mammalian Molecular biology Transformation (genetics) Cisplatin Mutagens |
| Zdroj: | Mutation research. 66(3) |
| ISSN: | 0027-5107 |
| Popis: | The anti-tumor agent cis-platinum (II) diamine dichloride caused dose-dependent toxicity in V79 Chinese hamster cells and in secondary Syrian hamster embryo cells. Chromosome aberrations were induced and positive dose—response relationships were observed for induction of sister-chromatid exchanges and 6-thioguanine-resistant mutations in V79 cells and morphologic transformation of secondary Syrian hamster embryo cells. These findings suggest that this chemical is a potential human carcinogen. |
| Databáze: | OpenAIRE |
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