New N-alkyl derivatives of amphotericin B. Synthesis and biological properties
| Autor: | Sławomir Milewski, Teresa Zieniawa, Pawel Sowinski, Edward Borowski, Wilfried A. König, Andrzej Czerwinski, Volker Sinnwell |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Pharmacology
chemistry.chemical_classification Antifungal Agents Chemistry Stereochemistry Biological activity Microbial Sensitivity Tests Saccharomyces cerevisiae behavioral disciplines and activities Chemical synthesis humanities In vitro Amphotéricine B Amphotericin B Biological property Candida albicans Drug Discovery Michael reaction medicine Alkyl medicine.drug |
| Zdroj: | The Journal of Antibiotics. 44:979-984 |
| ISSN: | 1881-1469 0021-8820 |
| DOI: | 10.7164/antibiotics.44.979 |
| Popis: | The synthesis of new N-alkyl amphotericin B derivatives obtained in the Michael addition reaction of the antibiotic with N-substituted maleimides is described and in vitro biological data are presented. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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