The relationship between glomerular IgG staining and poor prognostic findings in patients with IgA nephropathy: the data from TSN-GOLD working group
| Autor: | Turgutalp, Kenan, Cebeci, Egemen, Türkmen, Aydın, Derici, Ülver Boztepe, Seyahi, Nurhan, Eren, Necmi, Dede, Fatih, Güllülü, Mustafa, Baştürk, Taner, Şahin, Gülizar Manga, Yılmaz, Mürvet, Sipahi, Savaş, Şahin, Garip, Ulu, Sena Memnune, Tatar, Erhan, Gündogdu, Ali, Kazancıoğlu, Rümeyza Turan, Sevinç, Can, Güngör, Özkan, Şahin, İdris, Kutlay, Sim, Kurultak, İlhan, Aydın, Zeki, Altun, Bülent, Dursun, Belda, Yılmaz, Zülfükar, Uzun, Özcan, Süleymanlar, Gültekin, Candan, Ferhan, Sezer, Siren, Tanburoğlu, Derya Basak, Bicik, Zerrin, Taymez, Dilek Güven, Akcali, Esra, Oygar, Düriye Deren, İstemihan, Zülal, Bardak, Simge, Akçay, Ömer Faruk, Dincer, Mevlüt Tamer, Dervişoğlu, Erkan, Yenigün, Ezgi Çoşkun, Türkmen, Kültigin, Özturk, Savaş |
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| Přispěvatelé: | KAZANCIOĞLU, Rümeyza, Basturk, Taner, Ulu, Sena, Dicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıklar Ana Bilim Dalı, Yılmaz, Zülfükar |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Nephrology
Adult Male medicine.medical_specialty Kidney Glomerulus urologic and male genital diseases Gastroenterology Oxford Classification Nephropathy Glomerular IgG staining chemistry.chemical_compound Internal medicine Biopsy medicine Humans Deposition Retrospective Studies O-Glycosylation Proteinuria medicine.diagnostic_test Staining and Labeling business.industry Research Glomerular mesangium Albumin Glomerulonephritis IGA IgA nephropathy Middle Aged medicine.disease Prognosis the data from TSN-GOLD working group.- BMC nephrology cilt.22 sa.1 ss.352 2021 [Turgutalp K. Cebeci E. Turkmen A. Derici U. Seyahi N. Eren N. Dede F. Gullulu M. Basturk T. Sahin G. M. et al. -The relationship between glomerular IgG staining and poor prognostic findings in patients with IgA nephropathy] Diseases of the genitourinary system. Urology Cross-Sectional Studies chemistry Immunoglobulin G Uric acid Mesangial proliferative glomerulonephritis Female RC870-923 medicine.symptom business Renal prognostic factors |
| Zdroj: | BMC Nephrology BMC Nephrology, Vol 22, Iss 1, Pp 1-8 (2021) |
| Popis: | Background Galactose-deficient IgA1 (Gd-IgA1) has an increased tendency to form immunocomplexes with IgG in the serum, contributing to IgAN pathogenesis by accumulating in the glomerular mesangium. Several studies showed that glomerular IgG deposition in IgAN is an important cause of mesangial proliferation and glomerular damage. This study aims to determine the association of the positivity of IgG and the intensity of IgG staining with a poor renal prognosis. Methods A total of 943 IgAN patients were included in the study. Glomerular IgG staining negative and positive patients were compared using Oxford classification scores, histopathological evaluations, proteinuria, eGFR, albumin, blood pressures. IgG positive patients were classified as (+), (++), (+++) based on their staining intensity, and the association with the prognostic criteria was also evaluated. Results 81% (n = 764) of the patients were detected as IgG negative, while 19% (n = 179) were positive. Age, gender, body mass index, blood pressure, proteinuria, eGFR, uric acid values were similar in IgG positive and negative patients who underwent biopsy (p > 0.05). Intensity of glomerular IgG positivity was not found to be associated with diastolic and systolic blood pressure, urea, uric acid, age, eGFR, albumin, proteinuria (p > 0.05 for all, r = − 0.084, r = − 0.102, r = − 0.006, r = 0.062, r = 0.014, r = − 0.044, r = − 0.061, r = − 0.066, r = 0.150, respectively). There was no difference for histopathological findings between IgG (+), IgG (++), IgG (+++) groups (for all, p > 0.05). Conclusion Glomerular IgG negativity and positivity detected by routine IFM in IgAN patients is not associated with poor renal prognostic risk factors. |
| Databáze: | OpenAIRE |
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