Postoperative radiation as adjuvant treatment for carcinoma of the oral cavity larynx, and pharynx: Preliminary report of a prospective randomized trial
| Autor: | Pezner Rd, J D Beatty, Walter Lawrence, William A. Kokal, Daniel U. Riihimaki, G. A. Parker, Lipsett Ja, Jose J. Terz, Eisert D, James P. Neifeld |
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| Rok vydání: | 1988 |
| Předmět: |
Adult
Male Larynx medicine.medical_specialty Randomization medicine.medical_treatment law.invention Random Allocation Randomized controlled trial law Carcinoma medicine Humans Prospective Studies Prospective cohort study Laryngeal Neoplasms Aged Postoperative Care Clinical Trials as Topic business.industry Head and neck cancer Pharyngeal Neoplasms General Medicine Middle Aged medicine.disease Combined Modality Therapy Surgery Clinical trial Radiation therapy medicine.anatomical_structure Oncology Head and Neck Neoplasms Lymphatic Metastasis Carcinoma Squamous Cell Female Mouth Neoplasms Neoplasm Recurrence Local business |
| Zdroj: | Journal of Surgical Oncology. 38:71-76 |
| ISSN: | 1096-9098 0022-4790 |
| DOI: | 10.1002/jso.2930380202 |
| Popis: | A prospective randomized trial was performed in patients with advanced squamous cell carcinomas (SCC) of the oral cavity, larynx, and pharynx to examine the effect of adjuvant postoperative radiation therapy on locoregional recurrence and survival following "curative" resection. Fifty-one patients with stage III or IV SCC treated from 1981 through 1984 were randomized to receive either surgery alone (n = 27) or surgery with postoperative radiation (n = 24). Five patients were excluded from the study after randomization because of ineligibility or protocol violations. Overall recurrence rates of 55.6% and 36.8% were noted in the surgery and surgery with adjuvant radiotherapy arms, respectively (p = NS). This trend towards a higher recurrence rate in the surgery only arm was in part due to the development of lymph node metastases in the contralateral, nonoperated neck. Thus far, no significant differences in either locoregional or overall survival have been noted between the two treatment arms. In this preliminary analysis, adjuvant postoperative radiotherapy does not appear to improve disease-free or overall survival. |
| Databáze: | OpenAIRE |
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