Impact of adiposity and plasma adipocytokines on diabetic angiopathies in Japanese Type 2 diabetic subjects
| Autor: | Masaaki Eto, Yukiko Kanda, Michihiro Matsuki, Mieko Saito, K. Yamada, Fumiko Kawasaki, Masafumi Matsuda, Kohei Kaku |
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| Rok vydání: | 2004 |
| Předmět: |
Male
medicine.medical_specialty Endocrinology Diabetes and Metabolism Adipokine Adipose tissue Type 2 diabetes Diabetic angiopathy Body Mass Index Endocrinology Internal medicine Adipocytes Internal Medicine medicine Humans Diabetic Nephropathies Diabetic Retinopathy Adiponectin business.industry Microangiopathy Middle Aged medicine.disease Lipids Adipose Tissue Diabetes Mellitus Type 2 Cytokines Intercellular Signaling Peptides and Proteins Female Microalbuminuria Resistin business Diabetic Angiopathies |
| Zdroj: | Diabetic Medicine. 21:881-888 |
| ISSN: | 1464-5491 0742-3071 |
| DOI: | 10.1111/j.1464-5491.2004.01261.x |
| Popis: | Aims Adipocytokines, products from adipose tissue, have biological activities on the vascular system, and may affect diabetic angiopathy. In this study, we assessed the relationship between adiposity and plasma adipocytokine levels, and investigated the clinical significance of adiposity and plasma adipocytokine levels on diabetic micro- and macroangiopathy in Type 2 diabetic subjects. Methods We studied 231 Japanese Type 2 diabetic subjects (135 men and 96 women, aged 60.4 ± 12.3 years, body mass index 24.8 ± 5.2 kg/m2). We measured adipocytokine [adiponectin, leptin, resistin, and tumour necrosis factor (TNF)-α] levels, lipid profiles and urine albumin excretion. We also performed optic fundus examination and measured carotid intramedia thickness (IMT) using B-mode ultrasonography, and the localization of fat with abdominal computed tomography. A group of 93 subjects with microalbuminuria or overt proteinuria was compared with the other 148 to assess the effect on nephropathy. A group of 191 eyes with simple retinopathy or more advanced changes was compared with 263 eyes without retinal changes to assess the effect on retinopathy. Results Plasma adiponectin level was negatively correlated with both visceral (r = −0.37, P |
| Databáze: | OpenAIRE |
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