Poly ethylene glycol (PEG)-Related controllable and sustainable antidiabetic drug delivery systems

Autor: Ding Ying, Jiang Liu, Litao Zhang, Peng Yu, Yongmin Zhang, Yupeng Fu
Přispěvatelé: Tianjin University of Science and Technology (TUST), Institut Parisien de Chimie Moléculaire (IPCM), Chimie Moléculaire de Paris Centre (FR 2769), Institut de Chimie du CNRS (INC)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Chimie du CNRS (INC)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)
Rok vydání: 2021
Předmět:
Poly ethylene glycol
MESH: Diabetes Mellitus
Biocompatibility
MESH: Drug Delivery Systems
MESH: Molecular Structure
Nanotechnology
macromolecular substances
Polyethylene glycol
stimulating responsive release
01 natural sciences
Micelle
Polyethylene Glycols
03 medical and health sciences
chemistry.chemical_compound
Drug Delivery Systems
MESH: Hypoglycemic Agents
Drug Discovery
PEG ratio
Diabetes Mellitus
Humans
Hypoglycemic Agents
drug delivery system
sustainable release
Therapy efficacy
Micelles
030304 developmental biology
Pharmacology
Drug Carriers
0303 health sciences
MESH: Humans
Molecular Structure
antidiabetic
010405 organic chemistry
Chemistry
Organic Chemistry
MESH: Micelles
technology
industry
and agriculture
General Medicine
[SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences
PEG
0104 chemical sciences
3. Good health
MESH: Drug Carriers
MESH: Polyethylene Glycols
Drug delivery
Self-healing hydrogels
Zdroj: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2021, 217, pp.113372. ⟨10.1016/j.ejmech.2021.113372⟩
ISSN: 0223-5234
1768-3254
DOI: 10.1016/j.ejmech.2021.113372
Popis: International audience; Diabetes mellitus is one of the most challenging threats to global public health. To improve the therapy efficacy of antidiabetic drugs, numerous drug delivery systems have been developed. Polyethylene glycol (PEG) is a polymeric family sharing the same skeleton but with different molecular weights which is considered as a promising material for drug delivery. In the delivery of antidiabetic drugs, PEG captures much attention in the designing and preparation of sustainable and controllable release systems due to its unique features including hydrophilicity, biocompatibility and biodegradability. Due to the unique architecture, PEG molecules are also able to shelter delivery systems to decrease their immunogenicity and avoid undesirable enzymolysis. PEG has been applied in plenty of delivery systems such as micelles, vesicles, nanoparticles and hydrogels. In this review, we summarized several commonly used PEG-contained antidiabetic drug delivery systems and emphasized the advantages of stimuli-responsive function in these sustainable and controllable formations.
Databáze: OpenAIRE
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