Modular therapy approach in metastatic castration-refractory prostate cancer
| Autor: | Bernhard Walter, Anna Berand, W. F. Wieland, Albrecht Reichle, Reinhard Andreesen, Martin Vogelhuber, Sebastian Rogenhofer |
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| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Pyridines Urology medicine.medical_treatment Phases of clinical research Antineoplastic Agents Bone Neoplasms Kaplan-Meier Estimate Deoxycytidine Dexamethasone Metastasis Capecitabine Etoricoxib Lactones Prostate cancer medicine Humans Sulfones Aged Aged 80 and over Chemotherapy Pioglitazone business.industry Prostatic Neoplasms medicine.disease Surgery Treatment Outcome Fluorouracil Radionuclide therapy Disease Progression Drug Therapy Combination Thiazolidinediones business Orchiectomy Progressive disease medicine.drug |
| Zdroj: | World Journal of Urology. 28:745-750 |
| ISSN: | 1433-8726 0724-4983 |
| DOI: | 10.1007/s00345-010-0567-x |
| Popis: | The present multi-center phase II study was designed to support the hypothesis that networking agents which bind to ubiquitous accessible targets in metastatic castration-resistent prostate cancer (CRPC) may counteract neoplasia-specific aberrant cellular functions, thereby mediating PSA response. Patients with metastatic CRPC received low-dose chemotherapy with capecitabine 1 g twice daily plus dexamethasone 1 mg daily for 14 days every 3 weeks, COX-2 blockade with rofecoxib 25 mg (or etoricoxib 60 mg) daily combined with pioglitazone 60 mg daily, starting with day 1 + until disease progression. Thirty six patients with metastatic CRPC were enrolled; n = 18 (50%) had been extensively pretreated with radio- or radionuclide therapy, n = 16 (44%) with chemotherapies; and n = 8 patients (22%) were medically non-fit, having an ECOG-score of 0–2. Nine out of fifteen patients with PSA response >50% showed objective response. Median time to PSA response was 2.4 months (range 1.0–7.3 months). Two out of nine patients responding with PSA |
| Databáze: | OpenAIRE |
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