Exposure to arsenic during pregnancy and newborn mitochondrial DNA copy number: A birth cohort study in Wuhan, China

Autor: Jianing Bi, Senbei Yang, Mingyang Wu, Bin Zhang, Ruoling Chen, Yunyun Liu, Bingqing Liu, Wei Xia, Zhongqiang Cao, Lina Zhang, Lulin Wang, Youjie Wang, Lulu Song, Shunqing Xu
Rok vydání: 2020
Předmět:
Adult
Male
China
Mitochondrial DNA
DNA
Complementary
Environmental Engineering
DNA Copy Number Variations
Pregnancy Trimester
Third
Health
Toxicology and Mutagenesis
Urinary system
0208 environmental biotechnology
Mothers
Physiology
02 engineering and technology
010501 environmental sciences
Real-Time Polymerase Chain Reaction
Third trimester
DNA
Mitochondrial
01 natural sciences
Glycosphingolipids
Arsenic
Cohort Studies
Pregnancy
Humans
Environmental Chemistry
Medicine
0105 earth and related environmental sciences
business.industry
Infant
Newborn
Public Health
Environmental and Occupational Health
Infant
Records
General Medicine
General Chemistry
Fetal Blood
medicine.disease
Pollution
Early life
Mitochondria
020801 environmental engineering
Pregnancy Trimester
First
Maternal Exposure
Cord blood
Environmental Pollutants
Female
Pregnancy Trimesters
business
Birth cohort
Zdroj: Chemosphere. 243:125335
ISSN: 0045-6535
Popis: Background Arsenic (As) is a widely distributed environmental chemical with potentially different toxicities. However, little is known about the impact of maternal As exposure on newborn mitochondrial DNA copy number (mtDNAcn), which may lie on the pathway linking As exposure to adverse health impacts. Objectives We aimed to explore whether maternal As exposure was associated with newborn mtDNAcn. Methods We conducted a birth cohort study of 762 mother-infant pairs in Wuhan, China, 2013–2015. Cord blood mtDNAcn was determined using qPCR. Maternal urinary As levels in each trimester were quantified by ICP-MS. Multiple informant models were used to examine the associations of repeated urinary As levels with cord blood mtDNAcn. Results The median urinary As levels in the first, second, and third trimesters were 17.2 μg/L, 16.0 μg/L, and 17.0 μg/L, respectively. In the multivariate model, each doubling increase in the first-trimester urinary As level was associated with a 6.6% (95% CI: −12.4%, −0.5%) decrease in cord blood mtDNAcn. The highest versus lowest quintile of first-trimester urinary As level was associated with a 19.0% (95% CI: −32.9%, −2.2%) lower cord blood mtDNAcn. No significant associations of urinary As levels in the second and third trimesters with cord blood mtDNAcn were observed. The inverse relationship between first-trimester urinary As level and cord blood mtDNAcn was more pronounced among female infants. Conclusions First-trimester As exposure was related to decreased cord blood mtDNAcn. The potential health impacts of decreased mtDNAcn in early life need to be further clarified.
Databáze: OpenAIRE
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