Exposure to arsenic during pregnancy and newborn mitochondrial DNA copy number: A birth cohort study in Wuhan, China
Autor: | Jianing Bi, Senbei Yang, Mingyang Wu, Bin Zhang, Ruoling Chen, Yunyun Liu, Bingqing Liu, Wei Xia, Zhongqiang Cao, Lina Zhang, Lulin Wang, Youjie Wang, Lulu Song, Shunqing Xu |
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Rok vydání: | 2020 |
Předmět: |
Adult
Male China Mitochondrial DNA DNA Complementary Environmental Engineering DNA Copy Number Variations Pregnancy Trimester Third Health Toxicology and Mutagenesis Urinary system 0208 environmental biotechnology Mothers Physiology 02 engineering and technology 010501 environmental sciences Real-Time Polymerase Chain Reaction Third trimester DNA Mitochondrial 01 natural sciences Glycosphingolipids Arsenic Cohort Studies Pregnancy Humans Environmental Chemistry Medicine 0105 earth and related environmental sciences business.industry Infant Newborn Public Health Environmental and Occupational Health Infant Records General Medicine General Chemistry Fetal Blood medicine.disease Pollution Early life Mitochondria 020801 environmental engineering Pregnancy Trimester First Maternal Exposure Cord blood Environmental Pollutants Female Pregnancy Trimesters business Birth cohort |
Zdroj: | Chemosphere. 243:125335 |
ISSN: | 0045-6535 |
Popis: | Background Arsenic (As) is a widely distributed environmental chemical with potentially different toxicities. However, little is known about the impact of maternal As exposure on newborn mitochondrial DNA copy number (mtDNAcn), which may lie on the pathway linking As exposure to adverse health impacts. Objectives We aimed to explore whether maternal As exposure was associated with newborn mtDNAcn. Methods We conducted a birth cohort study of 762 mother-infant pairs in Wuhan, China, 2013–2015. Cord blood mtDNAcn was determined using qPCR. Maternal urinary As levels in each trimester were quantified by ICP-MS. Multiple informant models were used to examine the associations of repeated urinary As levels with cord blood mtDNAcn. Results The median urinary As levels in the first, second, and third trimesters were 17.2 μg/L, 16.0 μg/L, and 17.0 μg/L, respectively. In the multivariate model, each doubling increase in the first-trimester urinary As level was associated with a 6.6% (95% CI: −12.4%, −0.5%) decrease in cord blood mtDNAcn. The highest versus lowest quintile of first-trimester urinary As level was associated with a 19.0% (95% CI: −32.9%, −2.2%) lower cord blood mtDNAcn. No significant associations of urinary As levels in the second and third trimesters with cord blood mtDNAcn were observed. The inverse relationship between first-trimester urinary As level and cord blood mtDNAcn was more pronounced among female infants. Conclusions First-trimester As exposure was related to decreased cord blood mtDNAcn. The potential health impacts of decreased mtDNAcn in early life need to be further clarified. |
Databáze: | OpenAIRE |
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