Differences in topological properties of functional brain networks between menstrually-related and non-menstrual migraine without aura

Autor: Yu Zhao, Tao Xu, Dehua Li, Ling Zhao, Jiarong Du, Yi Wen, Huaqiang Liao, Wang Ziwen, Fanrong Liang, Zhang Yutong
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Migraine without Aura
Aura
Cognitive Neuroscience
Thalamus
Inferior frontal gyrus
Topology
03 medical and health sciences
Behavioral Neuroscience
Cellular and Molecular Neuroscience
0302 clinical medicine
Topological properties
Surveys and Questionnaires
Medicine
Humans
Radiology
Nuclear Medicine and imaging
reproductive and urinary physiology
030304 developmental biology
Neuroradiology
Original Research
0303 health sciences
Menstrually-related migraine without aura
medicine.diagnostic_test
Non-menstrual migraine without aura
business.industry
Neuropsychology
Functional brain network
Brain
Menstrual migraine
medicine.disease
Magnetic Resonance Imaging
Menstruation
Psychiatry and Mental health
Neurology
Migraine
Female
Neurology (clinical)
business
Functional magnetic resonance imaging
030217 neurology & neurosurgery
Zdroj: Brain Imaging and Behavior
ISSN: 1931-7565
1931-7557
Popis: Menstrually-related migraine without aura refers to a specific type of migraine that is associated with the female ovarian cycle. Compared with non-menstrual migraine without aura, in menstrually-related migraine without aura, there are additional attacks of migraine outside of the menstrual period. Menstrually-related migraine without aura tends to be less responsive to acute treatment and more prone to relapse than non-menstrual migraine without aura. Currently menstrually-related migraine without aura is treated no differently from any other migraine but, the differences in the central mechanisms underlying menstrually-related migraine without aura and non-menstrual migraine without aura remain poorly understood. Here, using resting-state functional magnetic resonance imaging and graph theory approaches, we aimed to explore the differences in topological properties of functional networks in 51 menstrually-related migraine without aura patients and 47 non-menstrual migraine without aura patients. The major finding of our study was that significant differences in topological properties between the two groups were mainly evident in the nodal centrality of the inferior frontal gyrus and the thalamus. Nodal centrality in inferior frontal gyrus was negatively correlated with Headache Impact Test questionnaire scores in the menstrually-related migraine without aura patients. Partial least squares correlation analysis revealed enhanced correlations of inferior frontal gyrus to pain-related behavior in the non-menstrual migraine without aura group, while within the menstrually-related migraine without aura group these effects were non-significant. These results indicate that the regulatory mechanisms in the central nervous system may differ between the two subtypes of migraine. The results provide novel insights into the pathophysiology of different subtypes of migraine, and could help us to enhance their clinical diagnosis and treatment.
Databáze: OpenAIRE
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