Inhibition of the activation of Hageman factor (factor XII) by human vascular endothelial cell culture supernates
| Autor: | Barbara Everson, Marlene M. Emanuelson, Oscar D. Ratnoff, James M. Anderson, Nicholas P. Ziats, Paula Embury, Charles J. Malemud |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Umbilical Veins
Enzyme activator Gallic Acid Organometallic Compounds medicine Humans Saphenous Vein Trypsin Cells Cultured Factor XII Sulfoglycosphingolipids Multidisciplinary Chemistry Culture Media Cell biology Enzyme Activation Endothelial stem cell Kinetics Secretory protein medicine.anatomical_structure Coagulation Biochemistry Cell culture Endothelium Vascular Research Article Blood vessel medicine.drug |
| Zdroj: | Proceedings of the National Academy of Sciences. 88:10740-10743 |
| ISSN: | 1091-6490 0027-8424 |
| Popis: | The supernatant fluid (conditioned medium) of cultured human vascular endothelial cells inhibits activation of Hageman factor (factor XII), whether by ellagic acid, bovine brain sulfatides, or bismuth subgallate; inhibition appears to be a property of one or more proteins in the culture supernates. This phenomenon may contribute to maintaining the fluidity of circulating blood by inhibiting surface activation of the intrinsic pathway of coagulation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|