Potent anti-inflammatory activity of sesquiterpene lactones from Neurolaena lobata (L.) R. Br. ex Cass., a Q’eqchi’ Maya traditional medicine
| Autor: | Federico Caal, Todd Pesek, Muhammd Asim, Marco Otarola Rojas, John T. Arnason, Christine Choueiri, Brendan Walshe-Roussel, Tony Durst, Victor Cal, Ammar Saleem |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Lipopolysaccharides
Cell Survival medicine.drug_class Positive control Plant Science Asteraceae Horticulture Biology Sesquiterpene Biochemistry Monocytes Anti-inflammatory Neurolaena Structure-Activity Relationship chemistry.chemical_compound Lobata medicine Humans Parthenolide Molecular Biology Cells Cultured Dose-Response Relationship Drug Molecular Structure Traditional medicine Tumor Necrosis Factor-alpha Anti-Inflammatory Agents Non-Steroidal General Medicine biology.organism_classification Plant Leaves chemistry Phytochemical Q eqchi maya Medicine Traditional Sesquiterpenes |
| Zdroj: | Phytochemistry. 92:122-127 |
| ISSN: | 0031-9422 |
| Popis: | The widespread use of Neurolaena lobata (L.) R. Br. ex Cass. by Q’eqchi’ Maya and indigenous healers throughout the Caribbean for inflammatory conditions prompted the study of the anti-inflammatory activity of this traditional medicine. The objectives of this study were to conduct a detailed ethnobotanical investigation of the uses of N. lobata by the Q’eqchi’ Maya of Belize for a variety of inflammatory symptoms and to evaluate the in vitro anti-inflammatory activity of leaf extract and isolated sesquiterpene lactones. The crude 80% EtOH extract of N. lobata leaves administered at 100 μg/mL reduced LPS-stimulated TNF-α production in THP-1 monocytes by 72% relative to the stimulated vehicle control. Isolated sesquiterpene lactones, neurolenins B, C + D, lobatin B and 9α-hydroxy-8β-isovalerianyloxy-calyculatolide were more active (IC50 = 0.17–2.32 μM) than the positive control parthenolide (IC50 = 4.79 μM). The results provide a pharmacological and phytochemical basis for the traditional use of this leaf for inflammatory conditions. |
| Databáze: | OpenAIRE |
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