The effect of hemostatic dressing prototypes for the uniformed services on selected blood coagulation parameters in pigs
| Autor: | A. Pomianowski, Piotr Holak, Joanna Głodek, Zbigniew Adamiak, M. Jalynski, Paweł Jastrzębski, Wioletta Krystkiewicz, Waldemar Zubrzycki, Danuta Bukowiecka |
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| Rok vydání: | 2016 |
| Předmět: |
Antithrombin III Activity
medicine.medical_specialty Swine medicine.medical_treatment Hemorrhage Fibrinogen Hemostatics 03 medical and health sciences 0302 clinical medicine 030202 anesthesiology Fibrinolysis Coagulopathy Medicine Animals Disseminated intravascular coagulation lcsh:Veterinary medicine General Veterinary business.industry Hemostatic Techniques Research General Medicine medicine.disease Thrombosis Bandages Surgery Coagulation 030220 oncology & carcinogenesis Hemostatic dressing lcsh:SF600-1100 Pigs business medicine.drug |
| Zdroj: | Acta Veterinaria Scandinavica Acta Veterinaria Scandinavica, Vol 59, Iss 1, Pp 1-5 (2017) |
| ISSN: | 1751-0147 |
| Popis: | Background Serious injuries accompanied by severe bleeding are life-threatening. Post-traumatic hemorrhage involves the risk of developing coagulopathy. Hemostatic dressings are widely used to minimize bleeding. The application of procoagulants in control of hemorrhage may lead to thrombosis or disseminated intravascular coagulation. The aim of this study was to evaluate the effect of hemostatic dressing prototypes on the porcine coagulation system. Results Fibrinogen and d-dimer concentrations were significantly higher in the experimental groups where hemostatic dressings were used in comparison with the control group. Considerable differences in antithrombin III activity and thrombin–antithrombin complex concentrations were also observed between groups. Conclusions The hemostatic dressing comprising modified seton impregnated with 18.0 g/m2 of procoagulant was most effective in preserving the physiological equilibrium between fibrinogenesis and fibrinolysis. |
| Databáze: | OpenAIRE |
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