Variations of Serum Oxidative Stress Biomarkers under First-Line Antituberculosis Treatment: A Pilot Study
| Autor: | Elena Camelia Stănciulescu, Catalina-Gabriela Pisoschi, Adina Turcu-Stiolica, Floarea Mimi Nitu, Marius Matei, Ana Marina Andrei, Ileana Monica Banita, Andreea-Daniela Meca |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
antioxidant Antioxidant medicine.medical_treatment 030106 microbiology lcsh:Medicine Medicine (miscellaneous) Oxidative phosphorylation Pharmacology medicine.disease_cause Article Superoxide dismutase 03 medical and health sciences chemistry.chemical_compound medicine TBARS oxidative stress glutathione chemistry.chemical_classification biology business.industry Glutathione peroxidase lcsh:R catalase Glutathione 030104 developmental biology tuberculosis superoxide-dismutase chemistry Catalase biology.protein business Oxidative stress |
| Zdroj: | Journal of Personalized Medicine Volume 11 Issue 2 Journal of Personalized Medicine, Vol 11, Iss 112, p 112 (2021) |
| ISSN: | 2075-4426 |
| DOI: | 10.3390/jpm11020112 |
| Popis: | Tuberculosis (TB) is one of the highest infectious burdens worldwide, and pathogenesis is yet incompletely elucidated. Bacilli dissemination is due to poor antioxidant defense mechanisms and intensified oxidative stress. There are few recent studies that analyzed and compared free radicals or antioxidant status before and after anti-TB treatment. Hence, the present study underlines the need to identify oxidative stress as it could be a useful tool in TB monitorisation. Thirty newly diagnosed patients with pulmonary TB were included after signing an informed consent. Blood was collected before receiving first-line anti-tubercular therapy (T0) and after 60 days (T2). Spectrophotometric methods were used to quantify oxidative parameters (TBARS—thiobarbituric acid reactive species) enzymatic antioxidants such as SOD (superoxide dismutase), CAT (catalase), GPx (glutathione peroxidase), and TAC (total antioxidant capacity) and non-enzymatic antioxidants such as GSH (reduced glutathione). A moderate positive correlation was found between GSH and TAC (r = 0.63, p-value = 0.046) and GSH and SOD (r = 0.64, p-value = 0.041) at T2. Increased values of GSH, CAT, and SOD were noted at T2 in comparison with T0, while GPx, TAC, and TBARS decreased at T2. A better monitorisation in TB could be based on oxidative stress and antioxidant status. Nevertheless, restoring redox host balance could reduce TB progression. |
| Databáze: | OpenAIRE |
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