Bacterial metabolic 'toxins': a new mechanism for lactose and food intolerance, and irritable bowel syndrome
| Autor: | Charles D. Cox, Kenneth Taylor Wann, Nasrin Vassel, Anthony K. Campbell, Stephanie Beatrix Matthews, I. B. Holland, John Green, J. Chaichi, Riffat Naseem |
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| Přispěvatelé: | Institut de génétique et microbiologie [Orsay] (IGM), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
MESH: Dietary Carbohydrates
Allergy Constipation Gastrointestinal Diseases Gene Expression Type 2 diabetes Toxicology Irritable Bowel Syndrome chemistry.chemical_compound Lactose Intolerance 0302 clinical medicine Lactose Irritable bowel syndrome 0303 health sciences digestive oral and skin physiology Pyruvaldehyde 3. Good health medicine.anatomical_structure [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology 030211 gastroenterology & hepatology medicine.symptom MESH: Food medicine.medical_specialty MESH: Pyruvaldehyde MESH: Gene Expression Bacterial Toxins Biology MESH: Calcium Signaling 03 medical and health sciences MESH: Irritable Bowel Syndrome Internal medicine MESH: Cell Proliferation MESH: Lactose Intolerance Dietary Carbohydrates medicine Humans [SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular Biology Calcium Signaling MESH: Gastrointestinal Diseases Cell Proliferation 030304 developmental biology Lactose intolerance MESH: Humans Bacteria medicine.disease Small intestine Food intolerance MESH: Bacteria Endocrinology chemistry MESH: Bacterial Toxins Food |
| Zdroj: | Toxicology Toxicology, Elsevier, 2010, 278 (3), pp.268-76. ⟨10.1016/j.tox.2010.09.001⟩ |
| ISSN: | 0300-483X |
| DOI: | 10.1016/j.tox.2010.09.001⟩ |
| Popis: | International audience; Lactose and food intolerance cause a wide range of gut and systemic symptoms, including gas, gut pain, diarrhoea or constipation, severe headaches, severe fatigue, loss of cognitive functions such as concentration, memory and reasoning, muscle and joint pain, heart palpitations, and a variety of allergies (Matthews and Campbell, 2000; Matthews et al., 2005; Waud et al., 2008). These can be explained by the production of toxic metabolites from gut bacteria, as a result of anaerobic digestion of carbohydrates and other foods, not absorbed in the small intestine. These metabolites include alcohols, diols such as butan 2,3 diol, ketones, acids, and aldehydes such as methylglyoxal (Campbell et al., 2005, 2009). These 'toxins' induce calcium signals in bacteria and affect their growth, thereby acting to modify the balance of microflora in the gut (Campbell et al., 2004, 2007a,b). These bacterial 'toxins' also affect signalling mechanisms in cells around the body, thereby explaining the wide range of symptoms in people with food intolerance. This new mechanism also explains the most common referral to gastroenterologists, irritable bowel syndrome (IBS), and the illness that afflicted Charles Darwin for 50 years (Campbell and Matthews, 2005a,b). We propose it will lead to a new understanding of the molecular mechanism of type 2 diabetes and some cancers. |
| Databáze: | OpenAIRE |
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