Linkage analysis of the genetic determinants of high density lipoprotein concentrations and composition: evidence for involvement of the apolipoprotein A-II and cholesteryl ester transfer protein loci
| Autor: | Yu Rong Xia, Jerome I. Rotter, Aldons J. Lusis, Beth Lokensgard, Cynthia De Meester, Siamac Daneshmand, Jane Brown, Xiangdong Bu, Donald L. Puppione, Richard J. Gray, Craig H Warden, Scott Teruya |
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| Rok vydání: | 1994 |
| Předmět: |
Male
Apolipoprotein E Apolipoprotein B Genetic Linkage Molecular Sequence Data Apolipoprotein A-II Locus (genetics) chemistry.chemical_compound High-density lipoprotein Gene mapping Cholesterylester transfer protein Genetics Humans Genetics (clinical) Glycoproteins Polymorphism Genetic Base Sequence biology nutritional and metabolic diseases Cholesterol Ester Transfer Proteins Apolipoproteins chemistry Low-density lipoprotein biology.protein Female lipids (amino acids peptides and proteins) Carrier Proteins Lipoproteins HDL |
| Zdroj: | Human Genetics. 93:639-648 |
| ISSN: | 1432-1203 0340-6717 |
| Popis: | We have tested for evidence of linkage between the genetic loci determining concentrations and composition of plasma high density lipoproteins (HDL) with the genes for the major apolipoproteins and enzymes participating in lipoprotein metabolism. These genes include those encoding various apolipoproteins (apo), including apoA-I, apoA-II, apoA-IV, apoB, apoC-I, apoC-II, apoC-III, apoE, and apo(a), cholesteryl ester transfer protein (CETP), HDL-binding protein, lipoprotein lipase, and the low density lipoprotein (LDL) receptor. Polymorphisms of these genes, and nearby highly polymorphic simple sequence repeat markers, were examined by quantitative sib-pair linkage analysis in 30 coronary artery disease families consisting of a total of 366 individuals. Evidence for linkage was observed between a marker locus D16S313 linked to the CETP locus and a locus determining plasma HDL-cholesterol concentration (P = 0.002), and the genetic locus for apoA-II and a locus determining the levels of the major apolipoproteins of HDL, apoA-I and apoA-II (P = 0.009 and 0.02, respectively). HDL level was also influenced by the variation at the apo(a) locus on chromosome 6 (P = 0.02). Thus, these data indicate the simultaneous involvement of at least two different genetic loci in the determination of the levels of HDL and its associated lipoproteins. |
| Databáze: | OpenAIRE |
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