IGF-1, IGFBP-3, VEGF and MMP-9 levels and their potential relationship with renal functions in patients with compensatory renal growth
| Autor: | Nevbahar Akcar, Ilknur Ak, Nurdan Kural, Ömer Çolak, Bilal Yildiz |
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| Rok vydání: | 2007 |
| Předmět: |
Male
Vascular Endothelial Growth Factor A medicine.medical_specialty Physiology medicine.medical_treatment Renal function Enzyme-Linked Immunosorbent Assay Urine Kidney Kidney Function Tests Nephrectomy Insulin-like growth factor-binding protein chemistry.chemical_compound Fibrosis Physiology (medical) Internal medicine medicine Humans Insulin-Like Growth Factor I Child Proteinuria Chi-Square Distribution biology business.industry General Medicine Recovery of Function medicine.disease Adaptation Physiological Vascular endothelial growth factor Endocrinology medicine.anatomical_structure Insulin-Like Growth Factor Binding Protein 3 chemistry Matrix Metalloproteinase 9 biology.protein Female medicine.symptom business |
| Zdroj: | Clinical physiology and functional imaging. 28(2) |
| ISSN: | 1475-0961 |
| Popis: | Summary Background: Mechanisms of compensatory renal growth (CRG) still remain a mystery. Various growth factors, including growth hormone, insulin-like growth factor-1 (IGF-1) have been implicated in different forms of CRG. Aims: To investigate the serum levels of IGF-1, vascular endothelial growth factor (VEGF – role in vascular remodelling), matrix metalloproteinase-9 (MMP-9 – essential for normal nephrogenesis) and correlation of renal function in patients with unilateral nephrectomized, agenesis and hypoplasic kidney. Methods: Thirty patients were included in this study. In group I, there were 10 patients with unilateral nephrectomy, while in group II, there were 10 patients with unilateral agenesis. As for group III, there were 10 patients with unilateral hypoplastic kidney. The serum levels of IGF-1, IGF-binding protein-3 (IGFBP-3), VEGF and MMP-9 were studied in all the cases. Clearance of creatinin (Ccr) and protein excretion were examined in the 24 h urine. CRG was determined with ultrasonography and scintigraphy. Twenty-six control subjects were also studied. Results: The levels of IGF-1, IGFBP-3, VEGF and MMP-9 were significantly higher in patients than in the control subjects (P |
| Databáze: | OpenAIRE |
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