Long-term Prognosis After Lung Transplantation: A Monocentric Study in 510 Patients
| Autor: | M.J. Cobos Ceballos, F. Montoro Ballesteros, A. Palomares Muriana, J.J. Sánchez Fernández, F. Santos Luna, C. Esteban Amarilla, J. Redel Montero, JM Vaquero Barrios |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Graft Rejection Male medicine.medical_specialty Adolescent medicine.medical_treatment Bronchiolitis obliterans Kaplan-Meier Estimate 03 medical and health sciences Postoperative Complications 0302 clinical medicine Interquartile range Internal medicine medicine Humans Lung transplantation Survival analysis Retrospective Studies Transplantation Univariate analysis business.industry Mortality rate Retrospective cohort study Middle Aged Prognosis medicine.disease Survival Analysis 030228 respiratory system Respiratory failure Multivariate Analysis Female Surgery business Lung Transplantation |
| Zdroj: | Transplantation Proceedings. 50:658-660 |
| ISSN: | 0041-1345 |
| Popis: | Introduction Lung transplantation is the final treatment option in patients with respiratory failure. Morbidity and mortality rates associated with the management of complications is high despite advances. Postoperative complications include acute transplant rejection, bronchiolitis obliterans, and infections. Because of that, the success of this treatment option depends on the correct choice of donor and candidates to receive a transplant. Objective This study aims to perform a survival analysis of transplanted patients in our center and determine predictive variables of mortality. Patients and Methods This study is a retrospective assessment of data collected from 510 patients at the Hospital University Reina Sofia from October 1993 to December 31, 2016. Patients who were retransplanted were excluded. We collected data regarding basal characteristics of the donors and candidates to receive a transplant. We analyzed the impact in terms of future survival of basal variables from donor and donor recipients. Results Five hundred ten patients were included (average age 44 ± 17 years, 69% male), with a maximum follow-up period of 21.6 years (average follow-up 4.52 years, interquartile ratio: 0.13 to 6.97 years). Two hundred twenty-seven patients died (54.3% of the total amount). The influence of donor's basal characteristics on mortality was analyzed; moreover, the relationship between basal variables and survival were analyzed using univariate analysis. Available variables were analyzed through multivariate analysis. Conclusion Lung transplantation is a treatment option with an acceptable risk of morbidity and mortality. Increased awareness of features of evolution could help to reduce postoperative complications. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect