Prognostic significance of longitudinal strain in dilated cardiomyopathy with recovered ejection fraction
| Autor: | Giuseppe Romano, Gianfranco Sinagra, Francesco Clemenza, Andrea Boscutti, Marco Merlo, Marco Gobbo, Davide Stolfo, Elena Deych, Andrew Perry, Diego Bellavia, Laura Ajello, Eluisa La Franca, Luigi Adamo, John Gorcsan, Marco Masè |
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| Přispěvatelé: | Merlo, Marco, Masè, Marco, Perry, Andrew, La Franca, Eluisa, Deych, Elena, Ajello, Laura, Bellavia, Diego, Boscutti, Andrea, Gobbo, Marco, Romano, Giuseppe, Stolfo, Davide, Gorcsan, John, Clemenza, Francesco, Sinagra, Gianfranco, Adamo, Luigi |
| Rok vydání: | 2021 |
| Předmět: |
Cardiomyopathy
Dilated Male medicine.medical_specialty Longitudinal strain Population Cardiomyopathy heart failure Ventricular Function Left Article Internal medicine medicine echocardiography Humans Longitudinal Studies education Survival analysis Retrospective Studies education.field_of_study Ejection fraction business.industry cardiomyopathy dilated systolic Dilated cardiomyopathy Stroke Volume Middle Aged medicine.disease Prognosis Echocardiography Heart failure Cardiology Risk of death Cardiology and Cardiovascular Medicine business |
| Zdroj: | Heart |
| ISSN: | 1468-201X |
| Popis: | ObjectivePatients with non-ischaemic dilated cardiomyopathy (NICM) may experience a normalisation in left ventricular ejection fraction (LVEF). Although this correlates with improved prognosis, it does not correspond to a normalisation in the risk of death during follow-up. Currently, there are no tools to risk stratify this population. We tested the hypothesis that absolute global longitudinal strain (aGLS) is associated with mortality in patients with NICM and recovered ejection fraction (LVEF).MethodsWe designed a retrospective, international, longitudinal cohort study enrolling patients with NICM with LVEF 50%). We studied the relationship between aGLS measured at the time of the first recording of a normalised LVEF and all-cause mortality during follow-up. We considered aGLS >18% as normal and aGLS ≥16% as of potential prognostic value.Results206 patients met inclusion criteria. Median age was 53.5 years (IQR 44.3–62.8) and 56.6% were males. LVEF at diagnosis was 32.0% (IQR 24.0–38.8). LVEF at the time of recovery was 55.0% (IQR 51.7–60.0). aGLS at the time of LVEF recovery was 13.6%±3.9%. 166 (80%) and 141 (68%) patients had aGLS ≤18% and 18%). In unadjusted Kaplan-Meier survival analysis, aGLS ConclusionsIn patients with NICM and normalised LVEF, an impaired aGLS at the time of LVEF recovery is frequent and associated with worse outcomes. |
| Databáze: | OpenAIRE |
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