White matter and information processing speed following treatment with cranial-spinal radiation for pediatric brain tumor
| Autor: | Donald J. Mabbott, Normand Laperriere, Adam Fleming, Nada Jabado, Douglas Strother, Nadia Scantlebury, Nicole Law, Juliette Hukin, Dina McConnell, Chris Fryer, Isabelle Montour-Proulx, Lily Riggs, Suzanne Laughlin, Daniel L. Keene, Fang Liu, Eric Bouffet |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Adolescent White matter 03 medical and health sciences 0302 clinical medicine Craniospinal Irradiation Neural Pathways medicine Humans Child Brain Neoplasms Information processing Wechsler Adult Intelligence Scale Repeated measures design Anatomy Combined Modality Therapy White Matter Diffusion Tensor Imaging Neuropsychology and Physiological Psychology medicine.anatomical_structure 030220 oncology & carcinogenesis Pediatric Brain Tumor Female Cognition Disorders Psychology Neuroscience 030217 neurology & neurosurgery Tractography Optic radiation Diffusion MRI |
| Zdroj: | Neuropsychology. 30:425-438 |
| ISSN: | 1931-1559 0894-4105 |
| DOI: | 10.1037/neu0000258 |
| Popis: | OBJECTIVE We compared the structure of specific white matter tracts and information processing speed between children treated for posterior fossa tumors with cranial-spinal radiation (n = 30), or with surgery +/- focal radiation (n = 29), and healthy children (n = 37). METHOD Probabilistic diffusion tensor imaging (DTI) tractography was used to delineate the inferior longitudinal fasciculi, optic radiation, inferior frontal occipital fasciculi, and uncinate fasciculi bilaterally. Information processing speed was measured using the coding and symbol search subtests of the Wechsler Intelligence Scales, and visual matching, pair cancellation, and rapid picture naming subtests of the Woodcock-Johnson Test of Cognitive Ability, 3rd revision. We examined group differences using repeated measures MANOVAs and path analyses were used to test the relations between treatment, white matter structure of the tracts, and information processing speed. RESULTS DTI indices of the optic radiations, the inferior longitudinal fasciculi, and the inferior fronto-occipital fasciculi differed between children treated with cranial-spinal radiation and children treated with surgery +/- focal radiation, and healthy controls (p = .045). Children treated with cranial-spinal radiation also exhibited lower processing speed scores relative to healthy control subjects (p = .002). Notably, we observed that group differences in information processing speed were related to the structure of the right optic radiation (p = .002). CONCLUSION We show that cranial-spinal radiation may have a negative impact on information processing speed via insult to the right optic radiations. (PsycINFO Database Record |
| Databáze: | OpenAIRE |
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