Growth Enhancement in Suppressor of Cytokine Signaling 2 (SOCS-2)-Deficient Mice Is Dependent on Signal Transducer and Activator of Transcription 5b (STAT5b)
| Autor: | Nicos A. Nicola, Patrick Bertolino, Jason Corbin, Helen W. Davey, Douglas J. Hilton, Donald Metcalf, Sylvia L. Asa, Christopher J. Greenhalgh, Warren S. Alexander, Timothy E. Adams |
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| Rok vydání: | 2002 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Blotting Western STAT5B Suppressor of Cytokine Signaling Proteins Stimulation Growth Biology Cell Line law.invention Mice STAT5B Gene Endocrinology law Internal medicine STAT5 Transcription Factor otorhinolaryngologic diseases medicine Animals RNA Messenger Insulin-Like Growth Factor I Phosphorylation Molecular Biology Skin Mice Knockout Suppressor of cytokine signaling 1 Body Weight Proteins General Medicine Milk Proteins DNA-Binding Proteins Repressor Proteins Cytokine Growth Hormone Pituitary Gland Hepatocytes Trans-Activators STAT protein Suppressor Female Signal transduction Gene Deletion Signal Transduction |
| Zdroj: | Molecular Endocrinology. 16:1394-1406 |
| ISSN: | 1944-9917 0888-8809 |
| Popis: | Mice lacking suppressor of cytokine signaling-2 (SOCS-2) exhibit accelerated postnatal growth resulting in adult mice that are 1.3 to 1.5 times the size of normal mice. In this study we examined the somatotrophic pathway to determine whether the production or actions of GH or IGF-I are altered in these mice. We demonstrated that SOCS-2−/− mice do not have elevated GH levels and suffer no major pituitary dysmorphogenesis, and that SOCS-2-deficient embryonic fibroblasts do not have altered IGF-I signaling. Primary hepatocytes from SOCS-2−/− mice, however, did have moderately prolonged signal transducer and activator of transcription 5 signaling in response to GH stimulation. Furthermore, the deletion of SOCS-2 from mice also lacking signal transducer and activator of transcription 5b had little effect on growth, suggesting that the action of SOCS-2 may be the regulation of the GH signaling pathway. |
| Databáze: | OpenAIRE |
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