BACTERICIDAL ACTIVITY OF RAT LEUCOCYTIC EXTRACTS
| Autor: | M. S. Silverman, M. Fishman, L. J. Cole |
|---|---|
| Rok vydání: | 1957 |
| Předmět: |
A lipoprotein
Phagocytosis Immunology Ether Mitochondrion Biology Article chemistry.chemical_compound Leukocytes medicine Animals Immunology and Allergy Lipase Bacteria Ultraviolet absorption Trypsin biology.organism_classification Anti-Bacterial Agents Mitochondria Rats chemistry Biochemistry biology.protein medicine.drug |
| Zdroj: | The Journal of Experimental Medicine |
| ISSN: | 1540-9538 0022-1007 |
| DOI: | 10.1084/jem.105.6.529 |
| Popis: | The bactericidal substance present in mitochondrial extracts from rat leucocytes was found to be non-dialyzable, fractionated at 30 per cent (NH4SO4 saturation and was able to withstand temperatures up to 100°C. The tentative identification of a lipoprotein as the responsible bactericidal substance is based on various observations; an ultraviolet absorption at a peak associated with alpha, beta unsaturated fatty acids, 205 to 208 mµ, inactivation of the bactericidal substance by ether treatment at –70°C. but not at 0°C. and inhibition of the bactericidal activity with lipase treatment as well as with trypsin. |
| Databáze: | OpenAIRE |
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