Nitric Oxide Scavenging Lignans from Vitex negundo Seeds
| Autor: | Ting Han, Qiao-Yan Zhang, Khalid Rahman, Cheng-Jian Zheng, Lu-Ping Qin, Bao-Kang Huang, Hong Zhang |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Lipopolysaccharides
Vitex negundo Pharmaceutical Science Pharmacognosy Nitric Oxide Lignans Analytical Chemistry Nitric oxide Vitex Mice Structure-Activity Relationship chemistry.chemical_compound Drug Discovery Botany Animals Phenols Medicinal plants Nuclear Magnetic Resonance Biomolecular Pharmacology Lignan Molecular Structure biology Traditional medicine Macrophages Alkaloid Verbenaceae Organic Chemistry biology.organism_classification Complementary and alternative medicine chemistry Seeds Molecular Medicine |
| Zdroj: | Journal of Natural Products. 72:1627-1630 |
| ISSN: | 1520-6025 0163-3864 |
| Popis: | A new phenyldihydronaphthalene-type lignan, vitexdoin A (1), a new phenylnaphthalene-type lignan alkaloid, vitedoamine B (2), four new phenylnaphthalene-type lignans, vitexdoins B-E (3-6), and four known lignan derivatives (7-10) were isolated from Vitex negundo seeds. Their structures were elucidated by detailed analyses of NMR, IR, and MS data. The ability of the isolates to prevent nitric oxide (NO) production by LPS-stimulated RAW 264.7 macrophages in a concentration-dependent manner was also studied. Compounds 5, 6, and 9 were among the most potent NO production inhibitors, with IC(50) values of 0.13, 0.15, and 0.11 microM, respectively. The introduction of free hydroxy groups plays a vital role in the potency of these compounds. |
| Databáze: | OpenAIRE |
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