Effects of intracaudate microinjections of 6-hydroxydopamine upon the suppression of lever pressing and upon passive avoidance conditioning in cats
| Autor: | C. Reyes Vazquez, H. Brust-Carmona, I. Zarco-Coronado |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Male
medicine.medical_specialty Clinical Biochemistry Caudate nucleus Stimulus (physiology) Toxicology Biochemistry Developmental psychology Injections Behavioral Neuroscience Hydroxydopamines Internal medicine medicine Avoidance Learning Animals Biological Psychiatry Sensitization Pharmacology Hydroxydopamine CATS Chemistry Dopaminergic Endocrinology medicine.anatomical_structure Microinjections Cats Conditioning Operant Female Caudate Nucleus Stimulus control |
| Zdroj: | Pharmacology, biochemistry, and behavior. 9(6) |
| ISSN: | 0091-3057 |
| Popis: | Recent studies have demonstrated that the caudate nucleus (CN) is an important element of the neuronal circuitry required for the acquisition and retention of a motor conditioned response (MCR). It has also been suggested that a normal level of dopamine in the CN is required for an animal to learn to suppress the MCR. In the experiments described here, cats were trained to press a lever (MCR) following the onset of a discriminative stimulus (light) which was reinforced with 0.5 ml of milk, and to refrain from pressing the lever in the absence of the stimulus (suppression of motor conditioned response, SMCR), since no reinforcement was given. After 3 sessions, bilateral microinjections of 5.0 μl of NaCl or different doses (5, 10, 20, 40, 80 or 160 μg) of 6-hydroxydopamine were made into the antero-ventral area of the head of CN. After 30–35 days the cats were submitted to a passive avoidance conditioning (PAC). Regarding the MCR, no differences were observed among the various groups; in relation to SMCR, the cats injected with 5, 10 and 20 μg of 6-OHDA showed a significant decrease in the number of lever pressings when compared with the NaCl group (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|