The fraction of lung cancer attributable to smoking in the Norwegian Women and Cancer (NOWAC) Study
| Autor: | Inger T. Gram, Idlir Licaj, Tonje Braaten, Eiliv Lund, Merethe Selnes Hansen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Cancer Research medicine.medical_specialty Passive smoking Lung Neoplasms Epidemiology Population medicine.disease_cause Article 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Confidence Intervals Prevalence Humans VDP::Medisinske Fag: 700 030212 general & internal medicine Prospective Studies Registries Lung cancer education Prospective cohort study Aged Proportional Hazards Models education.field_of_study Proportional hazards model business.industry Norway Incidence Hazard ratio Smoking Cancer Non-Smokers respiratory system Middle Aged medicine.disease Health Surveys respiratory tract diseases VDP::Medical disciplines: 700 Oncology 030220 oncology & carcinogenesis Attributable risk Female Tobacco Smoke Pollution business |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| Popis: | BackgroundWe examined the association between active and passive smoking and lung cancer risk and the population attributable fraction (PAF) of lung cancer due to active smoking, in the Norwegian Women and Cancer Study, a nationally representative prospective cohort study.MethodsWe followed 142,508 women, aged 31–70 years, who completed a baseline questionnaire between 1991 and 2007, through linkages to national registries through December 2015. We used Cox proportional hazards models, to estimate hazard ratios (HRs) with 95% confidence intervals (CIs). We calculated PAF to indicate what proportion of lung cancer cases could have been prevented in the absence of smoking.ResultsDuring the more than 2.3 million person-years of observation, we ascertained 1507 lung cancer cases. Compared with never smokers, current (HR 13.88, 95% CI 10.18–18.91) smokers had significantly increased risk of lung cancer. Female never smokers exposed to passive smoking had a 1.3-fold (HR 1.34, 95% CI 0.89–2.01) non- significantly increased risk of lung cancer, compared with never smokers. The PAF of lung cancer was 85.3% (95% CI 80.0–89.2).ConclusionMore than 8 in 10 lung cancer cases could have been avoided in Norway, if the women did not smoke. |
| Databáze: | OpenAIRE |
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