Case–Parent Trio Studies in Cleft Lip and Palate
| Autor: | Prashanth Cs, Mahamad Irfanulla Khan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Genetics
case–parent trio study 0303 health sciences medicine.medical_specialty education.field_of_study trio design family-based studies Clinical study design 030305 genetics & heredity Population population-based studies Review Article Biology 03 medical and health sciences Race (biology) Epidemiology Trait medicine Allele education Socioeconomic status 030304 developmental biology Genetic association cleft lip and palate |
| Zdroj: | Global Medical Genetics |
| ISSN: | 2699-9404 |
| Popis: | Cleft lip with or without cleft palate (CL/P) is one of the most common congenital malformations in humans involving various genetic and environmental risk factors. The prevalence of CL/P varies according to geographical location, ethnicity, race, gender, and socioeconomic status, affecting approximately 1 in 800 live births worldwide. Genetic studies aim to understand the mechanisms contributory to a phenotype by measuring the association between genetic variants and also between genetic variants and phenotype population. Genome-wide association studies are standard tools used to discover genetic loci related to a trait of interest. Genetic association studies are generally divided into two main design types: population-based studies and family-based studies. The epidemiological population-based studies comprise unrelated individuals that directly compare the frequency of genetic variants between (usually independent) cases and controls. The alternative to population-based studies (case–control designs) includes various family-based study designs that comprise related individuals. An example of such a study is a case–parent trio design study, which is commonly employed in genetics to identify the variants underlying complex human disease where transmission of alleles from parents to offspring is studied. This article describes the fundamentals of case–parent trio study, trio design and its significances, statistical methods, and limitations of the trio studies. |
| Databáze: | OpenAIRE |
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