Autologous bone marrow transplantation for childhood acute lymphoblastic leukaemia in Italy
| Autor: | M. V. Gazzola, F. Rossetti, G Sotti, Francesco Locatelli, Stefania Varotto, Andrea Pession, M. G. Petris, M. Andolina, Marta Pillon, Cornelio Uderzo, Marco Vignetti, Roberto Miniero, Roberto Rondelli, Giuseppe Basso, Chiara Messina, A. Amici, Giovanni Scarzello, R Destro, Marco Rabusin, Simone Cesaro, Giorgio Dini, Sandro Dallorso, Giovanna Meloni, Claudio Favre, Fulvio Porta, Luigi Zanesco |
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| Předmět: |
Transplantation
medicine.medical_specialty Univariate analysis business.industry Marrow transplantation Hematology medicine.disease Autologous bone Gastroenterology Surgery medicine.anatomical_structure El Niño Acute lymphocytic leukemia Internal medicine medicine Lymphoblastic leukaemia Effective treatment Bone marrow business |
| Zdroj: | Scopus-Elsevier |
| Popis: | From January 1984 to December 1994, ABMT was performed on 154 children (101 males, 53 females; median age 10, range 3-21 years) with ALL and registered for BMT by the AIEOP (Italian Association of Paediatric Haemato-Oncology). All patients were in CR: 98 were in 2nd CR and 56 were in >2nd CR. Fifteen children (9.7%) died of transplant-related mortality. Ninety-five patients (61.6%) relapsed at a median of 5 (range 1-42) months after ABMT. The 8-year EFS according to pre-BMT status was 34.6% (s.e. 4.9) for 2nd CR patients and 10.6% (s.e. 5.6) for patients in >2nd CR. By univariate analysis, site of relapse (isolated extramedullary (IE) vs BM: EFS = 68.5% vs 18.2%; P 2nd CR. By multivariate analysis, site of relapse was the only significant factor in 2nd CR patients (P < 0.0001). In conclusion, ABMT is an effective treatment after one early IE relapse. Few patients can be rescued after BM relapse. |
| Databáze: | OpenAIRE |
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