Risk of Vitamin A Toxicity From Candy-Like Chewable Vitamin Supplements for Children
| Autor: | Joannie Hui, Chi-Kong Lai, Pak Cheung Ng, Wing-Tat Poon, WL Yeung, Chung Mo Chow, Kwan Chee Allen Chan, Hugh Simon Lam, Albert Yan-Wo Chan |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Male
Risk Vitamin Retinyl Esters medicine.medical_specialty Drug overdose Candy Vitamin A overdose chemistry.chemical_compound Internal medicine Retinyl palmitate Humans Medicine Hypervitaminosis A Risk factor Vitamin A Biotransformation Vitamin a toxicity business.industry Retinol medicine.disease Endocrinology chemistry Child Preschool Dietary Supplements Ergocalciferols Pediatrics Perinatology and Child Health Toxicity Hong Kong Diterpenes Drug Overdose business Follow-Up Studies Tablets |
| Zdroj: | Pediatrics. 118:820-824 |
| ISSN: | 1098-4275 0031-4005 |
| Popis: | Numerous vitamin supplements are available over-the-counter to the general public. Some such supplements are available as candy-like chewable preparations to encourage consumption by children. We report 3 cases of overdose of such preparations. Each patient had taken an estimated 200000 to 300000 IU of vitamin A. Their circulating vitamin A (retinol and retinyl palmitate) concentrations were monitored over a 6-month period. There were no clinical or biochemical complications noted. However, there were marked increases in both retinol and retinyl palmitate concentrations above age-related reference ranges. In particular, it took 1 to 3 weeks for the serum retinol concentrations to peak and many months for them to normalize. Parents should be warned about the dangers of excessive vitamin consumption. Clinicians should be aware of the late peak in serum retinol concentrations, which may lead to late complications of vitamin A overdose. |
| Databáze: | OpenAIRE |
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