A Near-Haploid Bone Marrow Karyotype in Systemic Mast Cell Disease: Is It Characteristic of the Disease or an Incidental Finding?
| Autor: | Silloo B. Kapadia, Steven H. Swerdlow, Maureen E. Sherer, Niel Wald, Sofia Shekhter-Levin, W.Victoria Li, Susanne M. Gollin, Edward D. Ball |
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| Rok vydání: | 1998 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Malignant Mastocytosis Clone (cell biology) Bone Marrow Cells Chromosome Disorders Disease Haploidy Biology Fatal Outcome Genetics medicine Humans Molecular Biology Chromosome Aberrations Mosaicism Cytogenetics Karyotype Mast cell Chromosome Banding medicine.anatomical_structure Karyotyping Immunology Immunohistochemistry Bone marrow Mastocytosis |
| Zdroj: | Cancer Genetics and Cytogenetics. 103:124-129 |
| ISSN: | 0165-4608 |
| DOI: | 10.1016/s0165-4608(97)00386-5 |
| Popis: | We present the case of a 40-year-old man with aggressive systemic mast cell disease. The patient had a predominant near-haploid clone in his bone marrow cells, detected by cytogenetic analysis performed at the time of diagnosis. The similarities between this case and a previously published case of near-haploidy in a patient with malignant mastocytosis suggest that near-haploidy may be a characteristic of aggressive systemic mast cell disease rather than an incidental finding. |
| Databáze: | OpenAIRE |
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