Genetic polymorphism of urokinase-type plasminogen activator is interacting with plasminogen activator inhibitor-1 to raise risk of cervical neoplasia
| Autor: | Yi Torng Tee, Po Hui Wang, Hsiu Ting Tsai, Hung Ting Lin, Shun-Fa Yang, Tsung Ho Ying, Yi-Hsien Hsieh, Long Yau Lin |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Uterine Cervical Neoplasms medicine.disease_cause Polymerase Chain Reaction Polymorphism Single Nucleotide Risk Assessment chemistry.chemical_compound Risk Factors Polymorphism (computer science) Plasminogen Activator Inhibitor 1 Odds Ratio medicine Humans Genetic Predisposition to Disease Allele Alleles Aged Cervical cancer Urokinase business.industry General Medicine Middle Aged medicine.disease Urokinase-Type Plasminogen Activator Urokinase receptor Oncology chemistry Plasminogen activator inhibitor-1 Immunology Cancer research Female Surgery Carcinogenesis business Plasminogen activator Polymorphism Restriction Fragment Length medicine.drug |
| Zdroj: | Journal of Surgical Oncology. 106:204-208 |
| ISSN: | 0022-4790 |
| Popis: | Background and Objectives To evaluate the impact of plasminogen activator (PA) system genes, including urokinase plasminogen activator (uPA), uPA receptor (uPAR), and plasminogen activator inhibitor-1 (PAI-1) gene polymorphisms in patients with the cervical neoplasia. Methods In total, 336 blood samples were collected from healthy women and 136 patients with cervical neoplasia to analyze the gene polymorphisms of representative PA system genes. Results There was no significant association between cervical neoplasia cases and gene polymorphisms of uPA, uPAR and PAI-1 genes as well as to the carcinogenesis of cervical if the cervical neoplasia cases were stratified to HSILs and invasive cancer cases. However, we found a mutual interaction between uPA/PAI-1 genes, which women carrying the uPA/PAI-1 CC/4G4G allele had a 1.70-fold higher risk (OR = 1.70; 95% CI 1.04–2.79) of cervical neoplasia compared with those carrying the CC/4G5G allele. Conclusions Individuals with uPA/PAI-1 CC/4G5G allele were in high susceptibility for cervical neoplasia. The combined polymorphism of uPA/PAI-1 might diminish the ability of PAI-1 to inhibiting cervical cancer carcinogenesis when PAI-1 alone as the role of inhibitor. J. Surg. Oncol. 2012; 106:204–208. © 2012 Wiley Periodicals, Inc. |
| Databáze: | OpenAIRE |
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